Product Portfolio

Raw materials for mRNA therapeutics and vaccines

mRNA raw materials

GMP Grade and fit-for-purpose reagents for manufacturing of mRNA therapeutics

After decades of development, mRNA therapeutics were propelled into the global spotlight by the SARS-CoV-2 pandemic. From vaccines and immunotherapies to protein replacement and cell reprogramming, interest in mRNA manufacturing has surged. This creates immense opportunity, but also growing competition and evolving regulations.


To lead in this fast-paced environment, breakthrough science is not enough. Success hinges on development speed and uncompromising product safety.

As a long-standing global supplier of raw materials our expertise is providing the foundation to scale your ideas. We help you strengthen your supply chain, ease transfers to manufacturing, secure continuous production, and create consistently high-quality products.

This is the “why” of CustomBiotech: GMP Grade and fit-for-purpose raw materials to seize opportunities that improve healthcare.

 

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The shortest path to mRNA therapeutic success starts with high quality raw materials: mRNA reagents portfolio at a glance

The shortest path to mRNA therapeutic success starts with high quality raw materials: mRNA reagents portfolio at a glance


Restriction endonuclease Xba I

from Xanthomonas campestris pv. Badrii, expressed in E. coli, solution

Product

GMP Grade

Animal-origin-free
AOF1
Antibiotic-free Tested for RNase/
DNase activity

Extended impurity testing2

T7 RNA Polymerase, rec. Yes Yes Yes Yes Yes
Pyrophosphatase, rec. Yes Yes Yes Yes Yes
RNase Inhibitor, rec. Yes Yes Yes Yes Yes
SP6 RNA Polymerase, rec. Yes Yes Yes Yes Yes
Nucleotides:
ATP, 100mM, pH 8.3 Yes Yes Yes Yes Yes
CTP, 100mM, pH 8.3 Yes Yes Yes Yes Yes
GTP, 100mM, pH 8.3 Yes Yes Yes Yes Yes
UTP, 100mM, pH 8.3 Yes Yes Yes Yes Yes
ATP, 325 mM, pH 8.3 Yes Yes Yes Yes Yes
CTP, 325 mM, pH 8.3 Yes Yes Yes Yes Yes
GTP, 325 mM, pH 8.3 Yes Yes Yes Yes Yes
UTP, 325 mM, pH 8.3 Yes Yes Yes Yes Yes
N1-Methyl-Pseudo-UTP, AOF Yes Yes Yes Yes Yes
Pseudo-UTP, AOF - Yes Yes Yes Yes
1 For details see certificates of origin. 2 Includes e.g. testing for bioburden, endotoxin, heavy metals, host-cell DNA, host-cell protein, if applicable

Product

GMP Grade

Animal-origin-free
Antibiotics-free Tested for RNase /
DNAse activity
Extended impurity testing
Proteinase K, rec. Yes Yes Yes Yes Yes
DNase I, rec. Yes Yes Yes Yes Yes

Discover Roche NTPs: Animal-origin-free & GMP Grade

mrna nucleotides production

> 30 years of experience, substainable production and a brand new NTP production facility.

Find out how you can benefit from including our NTPs AOF in your manufacturing processes

Find out what GMP Grade and fit-for-purpose means for our mRNA reagents

mrna

A core commitment to quality, safety and efficacy with advanced quality mRNA reagents.

Read about our ISO13485:2016 certified QMS and more

Learn about the revolutionary potential of mRNA as a platform for biopharma

mrna

mRNA technology opportunities in therapeutics, ATMPs or vaccine applications.

Read about mRNA technology and related manufacturing processes

Meet Roche CustomBiotech experts from mRNA raw materials development and production

First hand insights into nucleotide production at biotechnology center Roche Penzberg
Listen to Roche experts
Benefit from advanced biotransformation processes for nucleotide production
Listen to Roche experts

Regulatory disclaimers are listed on the respective product pages.

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