mRNA therapeutics - from development to manufacturing
Though discovered over 50 years ago, mRNA has only recently entered the limelight as a potential therapeutic agent. in vitro transcribed mRNAs are engineered to elicit protein expression either in immune cells as a new front to treat cancer and combat infections, or in other tissues to improve replacement therapies.
The novelty of mRNAs as therapeutic agents entails uncertainties for their introduction to market and a seamless transition from development to manufacturing is key to success.
Selecting the right critical raw materials during the development of these new drug modalities with the foresight to smoothly transition into a routine manufacturing process may be a pivotal decision.
Scale and quality for industrial use
Whether for development or large-scale mRNA production, our raw materials meet strict manufacturing and quality criteria, perform in narrow specifications and are delivered at the right scale and across the globe. Focus on the development of your drug and rely on us and our raw materials to facilitate every step on your path to market.
- Manufactured under time-tested, state-of-the-art GMP quality standards
- Highly consistent from lot-to-lot
- Available in scale and quality for every stage – from development to manufacturing
- Backed by the expertise and know-how of a global pioneer in diagnostics and pharmaceuticals
Focus on the development of your drug and rely on us and our raw materials to facilitate every step on your path to market.
Reagents for mRNA therapeutics from Roche CustomBiotech
|Product||Animal-free*||ß-Lactam antibiotic-free||Tested for RNase / DNAse activity||Extended impurity testing****|
|T7 RNA Polymerase,
rec. GMP Grade
|Pyrophosphatase, rec., GMP Grade
|RNase Inhibitor, rec., GMP Grade - in development||✓||✓||✓||✓|
|DNase I, rec., GMP Grade||-**||✓||✓||planned|
|Ribonucleotides, 100 mM:|
|ATP, GMP Grade||-**/***||✓||✓||✓|
|CTP, GMP Grade||-**/***||✓||✓||✓|
|GTP, GMP Grade||-**/***||✓||✓||✓|
|UTP, GMP Grade||-**/***||✓||✓||✓|
Matching CustomBiotech products
|T7 RNA Polymerase / soon: SP6 RNA Polymerase
Pyrophosphatase / Alkaline Phosphatase
(ATP, CTP, GTP, UTP)
Modified ribonucleotides (N1-Methylpseudo UTP, Pseudo-UTP contact us)
Capping enzymes and ready-to-use IVT reaction buffers contact us
IVT reaction buffer or single components: MgCl2
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