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In mRNA in vitro synthesis applications, it helps purify the mRNA by digesting the DNA impurities in the reaction mix. In other molecular diagnostics applications, DNase I can be used to prepare genomic DNA-free RNA templates for RT-PCR.", "Language": "en", "Country": "XG", "Code": "Applications" }, { "Name": "Benefits", "Value": "Achieve reliable results with pure, undegraded and stable RNA. Rely on the highly purified and rigorously tested product that excludes RNase activity ensuring high yield and quality of your RNA.
  • animal-origin-free (AOF)
  • free of antibiotics
  • extended testing for impurities
  • manufactured under GMP
  • supplied with supplementary documents for regulatory submissions.
", "Language": "en", "Country": "XG", "Code": "Benefits" }, { "Name": "Specification", "Value": "Appearance: Colorless to slightly yellowish, solution
Volume activity (calf thymus DNA): 12-16 kU/mL (Kunitz)
Identity: Confirmed
Unit Definition: One unit according to Kunitz is the amount of enzyme required to hydrolyze the calf thymus DNA at 25°C and pH 5.0 to produce an increase of 0.001/min extinction coefficient at 260 nm under the test conditions.
Protein (abs. 280 nm): ≥ 1.0 mg/mL
Purity (SDS-PAGE): ≥ 95 %
Proteases (up to 50 U resorufin-marked casein after 17 h; 37°C): Not detectable
Ribonucleases (up to 10 U with MS II RNA/4 h / 37°C): Not detectable
Endotoxins: < 5 EU/mL
Bioburden: < 5 CFU/mL
Host cell protein: ≤ 100 ppm
Heavy metals (Ni, Co, V): ≤ 10 ppm
Stability: At -15 to -25°C within specification range for 18 months.", "Language": "en", "Country": "XG", "Code": "Specification" }, { "Name": "CB - Order Information", "Value": "09852093103: Will be supplied as 'DNase I rec., GMP Grade AOF'. Unit of measure is \"mL\".
09873562001:  Will be supplied as 'DNase I rec., GMP Grade AOF. 200 kU', Unit of measure is \"PC\".", "Language": "en", "Country": "XG", "Code": "CB - Order Information" } ] } } ] }

DNase I, rec., GMP Grade, AOF

from bovine pancreas, recombinant, expressed in Pichia pastoris, solution

DNase I, rec., GMP Grade, AOF
Reliable DNA digestion

DNase I is an essential enzyme for efficient digestion of DNA during RNA purification. For any sensitive RNA-based application, the quality of input RNA matters. Manufactured in GMP Grade quality and without the use of antibiotics, this Roche CustomBiotech DNase I is especially developed to meet the needs of the stringent mRNA therapeutics and vaccine manufacturers.

Achieve reliable results with pure, undegraded and stable RNA. Rely on the highly purified and rigorously tested product that excludes RNase activity ensuring high yield and quality of your RNA.

Produced using validated manufacturing and cleaning processes up to the final filling step and released under stringent final QC checks. Know that you are getting consistent quality every time.

From the generation of the master cell bank to the final filling, noanimal-derived materials are used in the process. This greatly simplifies your risk analysis.

During fermentation, no antibiotics are used. Therefore, allergic reactions to antibiotics is not a factor in your overall risk analysis.

Tested during final QC-release for the absence of impurities such as RNases, proteases, host cell protein, bioburden, heavy metals, or endotoxins. Work with an enzyme at peak performance that poses no risk to downstream processing.

We work with you to provide the necessary technical documents for your regulatory submissions.

Changing reagent quality between pre-clinical development and commercialization poses a risk. Secure your processes by using the best available quality from the start.

Ordering Information

Technical documents

for certificates, method sheets (instructions for use), safety data sheets and software downloads
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