For further processing only. Others Pseudo-UTP AOF Pseudo-UTP, AOF PID00000322 sodium salt, 100 mM, solution 09 754 334 103 9 754 334 103 09754334103 9754334103 09754334103 pseudoUTP, 100 mM pH 8.3, AOF, 100 mL pseudoUTP, 100 mM pH 8.3, AOF, 100 mL Reagents, kits 100 mL Not Available CustomBiotech product. Please contact your local representative. Will be supplied as "pseudoUTP, 100 mM pH 8.3, AOF, 100 mL". Unit of measure is "mL" 09 538 798 103 9 538 798 103 09538798103 9538798103 09538798103 pseudoUTP, 100 mM pH 8.3, AOF, 1 mL pseudoUTP, 100 mM pH 8.3, AOF, 1 mL Reagents, kits 1.0 mL Not Available CustomBiotech product. Please contact your local representative. Will be supplied as "pseudoUTP, 100 mM pH 8.3, AOF, 1 mL". Unit of measure is "piece" 1175-34-4 (free acid) en Appearance: Clear, colorless solutionpH value: 8.1–8.5Pseudo-UTP (A262; pH 7.0 ε= 7.5 [L x mmol-1 x cm-1]): 100–110 mmol/LPseudo-UTP (HPLC): ≥ 97 area%Identity (HPLC-MS): CorrespondsDNases/RNases: NegativeNicking activity: NegativeFunctional transcription assay: Corresponds to specificationProteases: Not detectableExonucleases: Not detectableEndotoxins: ≤ 2 EU/mLBioburden: ≤ 5 CFU/mLHeavy metals (Ni, V): ≤ 10 ppmStability: At -15 to -25°C within specification range for 12 months. en Modified UTP for the use in mRNA synthesis. en Use this modified UTP for the synthesis of mRNA for therapeutics or vaccines. It is designed to meet the specific needs of the pharmaceutical industry (fit-for-purpose):animal-origin-free (AOF)ß-Lactam-antibiotic freeextended testing for impuritiesvalidated QC release methods and cleaning validationsupplied with supplementary documents for regulatory submissions en This modified UTP can replace UTP in in-vitro-transcription reactions, e.g. for manufacturing mRNA therapeutics and vaccines. This RNA modification provides enhanced protein expression and reduced unwanted immunogenicity against the mRNA molecule itself. It represents an alternative to N1-Methyl-Pseudo-UTP which has proven its efficacy in Covid-19 vaccines. en

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Pseudo-UTP, AOF

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