Product Portfolio

In vitro glycoengineering of therapeutic proteins

In vitro glycoengineering illustration

Take control of glycosylation with in vitro glycoengineering  


Variation in glycosylation can impact the safety and efficacy profiles of a therapeutic product. With the right tools, glycosylation management can be uncoupled from the entangled processes of fermentation allowing you to pursue separate strategies to optimize glycosylation and yield, granting greater control over each.

Certain glycoforms can be enriched in downstream processing using discrete enzymatic reactions with clear kinetics and predictable outcomes. Resources are no longer wasted on uncertain tweaking of the bioprocess, leading to faster development as well as improved control of the manufacturing process.
 

View products

Contact Us

Downloads

Possibilities in glycosylation

View video

Optimization of glycosylation

View video

IVGE scale up and value

View video
Mycoplasma rendering

Glycosylation impacts the safety and efficacy of therapeutic proteins, yet traditional cell line optimization is often time-consuming and detrimental to yield. CustomBiotech offers a precise alternative: in vitro glycoengineering (IVGE).

This downstream process uses discrete enzymatic reactions to enrich specific glycoforms, delivering predictable kinetics while minimizing bioproduction waste.

In this GEN webinar LakePharma experts present data from successful case studies applying the IVGE process to gram-scale antibody production.

The tools to steer glycosylation - Roche CustomBiotech toolbox


The CustomBiotech in vitro glycosylation toolbox is a portfolio of well-characterized enzymes and activated sugars designed for specific and efficient alteration of sugar moieties.

Developed in partnership with Roche Pharma to meet quality and manufacturing requirements of the biopharmaceutical industry, the toolbox is the product of an ongoing, innovative program aimed at facilitating controlled manipulation of glycopatterns.

The glycosyltransferases and glycosidases in the portfolio have demonstrated high activity on a variety of glycoproteins, meet stringent pharmaceutical standards, and are available in gram to kilogram amounts and GMP Grade quality upon request.

You might be interested in

Read this PLoS article describing the use of IVGE to compare the effects of different glycoforms.
...
    ...

    Regulatory disclaimers are listed on the respective product page.

    Found 0 results in
    Filters
    ...
      ...