FcRn Column - List of Publications

1) Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies. Schlothauer T, Rueger P, Stracke JO, Hertenberger H, Fingas F, Kling L, Emrich T, Drabner G, Seeber S, Auer J, Koch S, Papadimitriou A. MAbs. 2013 Jul-Aug;5(4):576-86. doi: 10.4161/mabs.24981. Epub 2013 May 29.
2) A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies. Stracke J, Emrich T, Rueger P, Schlothauer T, Kling L, Knaupp A, Hertenberger H, Wolfert A, Spick C, Lau W, Drabner G, Reiff U, Koll H, Papadimitriou A. MAbs. 2014;6(5):1229-42. doi: 10.4161/mabs.29601. Epub 2014 Oct 30
3) Investigating the interaction between the neonatal Fc receptor and monoclonal antibody variants by hydrogen/deuterium exchange mass spectrometry. Jensen PF, Larraillet V, Schlothauer T, Kettenberger H, Hilger M, Rand KD. Mol Cell Proteomics. 2015 Jan;14(1):148-61. doi: 10.1074/mcp.M114.042044. Epub 2014 Nov 6.
4) Charge-mediated influence of the antibody variable domain on FcRn-dependent pharmacokinetics. Schoch A, Kettenberger H, Mundigl O, Winter G, Engert J, Heinrich J, Emrich T. Proc Natl Acad Sci U S A. 2015 May 12;112(19):5997-6002. doi: 10.1073/pnas.1408766112. Epub 2015 Apr 27
5) Conformational Destabilization of Immunoglobulin G Increases the Low pH Binding Affinity with the Neonatal Fc Receptor. Walters BT, Jensen PF, Larraillet V, Lin K, Patapoff T, Schlothauer T, Rand KD, Zhang J. J Biol Chem. 2016 Jan 22;291(4):1817-25. doi: 10.1074/jbc.M115.691568. Epub 2015 Dec 1
6) Multi-Angle Effector Function Analysis of Human Monoclonal IgG Glycovariants. Dashivets T, Thomann M, Rueger P, Knaupp A, Buchner J, Schlothauer T. PLoS One. 2015 Dec 11;10(12):e0143520. doi: 10.1371/journal.pone.0143520. eCollection 2015
7) Functional assessment of antibody oxidation by native mass spectrometry. Haberger M, Heidenreich AK, Schlothauer T, Hook M, Gassner J, Bomans K, Yegres M, Zwick A, Zimmermann B, Wegele H, Bonnington L, Reusch D, Bulau P. MAbs. 2015;7(5):891-900. doi: 10.1080/19420862.2015.1052199. Epub 2015 May 22.
8) Determination of critical quality attributes for monoclonal antibodies using quality by design principles. Alt N, Zhang TY, Motchnik P, Taticek R, Quarmby V, Schlothauer T, Beck H, Emrich T, Harris RJ. Biologicals. 2016 Sep;44(5):291-305. doi: 10.1016/j.biologicals.2016.06.005. Epub 2016 Jul 25. Review
9) A Two-pronged Binding Mechanism of IgG to the Neonatal Fc Receptor Controls Complex Stability and IgG Serum Half-life. Jensen PF, Schoch A, Larraillet V, Hilger M, Schlothauer T, Emrich T, Rand KD. Mol Cell Proteomics. 2017 Mar;16(3):451-456. doi: 10.1074/mcp.M116.064675. Epub 2017 Jan 6
10) Impact of SPR biosensor assay configuration on antibody: Neonatal Fc receptor binding data. Wang X, McKay P, Yee LT, Dutina G, Hass PE, Nijem I, Allison D, Cowan KJ, Lin K, Quarmby V, Yang J. MAbs. 2017 Feb/Mar;9(2):319-332. doi: 10.1080/19420862.2016.1261774. Epub 2016 Dec 21
11) Pharmacokinetic de-risking tools for selection of monoclonal antibody lead candidates. Dostalek M, Prueksaritanont T, Kelley RF. MAbs. 2017 May 2:1-11. doi: 10.1080/19420862.2017.1323160. [Epub ahead of print]
12) Detailed Characterization of Monoclonal Antibody Receptor Interaction Using Affinity Liquid Chromatography Hyphenated to Native Mass Spectrometry. Gahoual R, Heidenreich AK, Somsen GW, Bulau P, Reusch D, Wuhrer M, Haberger M. Anal Chem. 2017 May 16;89(10):5404-5412. doi: 10.1021/acs.analchem.7b00211. Epub 2017 Apr 26
13) Evaluation of an FcRn affinity chromatographic method for IgG1-type antibodies and evaluation of IgG variants. Cymer F, Schlothauer T, Knaupp A, Beck H. BIOANALYSIS 13 Sep 2017 https://doi.org/10.4155/bio-2017-0109 [ahead of print]