Clinical Chemistry Assays

Measuring enzyme activity in serum and plasma is one of the major tasks in the clinical laboratory. These enzymes are normally intracellular and present in the serum only in low concentrations. In the patient, elevated enzyme activities in serum give important information about the disease and treatment options.

Nitrogenous metabolites are normally cleared from the body by the kidney. Elevated plasma or serum concentrations of these metabolites are an indicator of impaired kidney function. Ammonia on the other hand, serves as an indicator of liver disease.

Glucose is the most prominent analyte that is formed during carbohydrate metabolism and one of the key players in diabetes care. Use Roche raw materials in assays for glucose and galactose, and also test for lactate that is an intermediary in carbohydrate metabolism.

Lipids are vital to all aspects of life and are also involved in major human disorders, including atherosclerosis, as well as cerebrovascular and peripheral vascular diseases. Measuring both triglycerides and total cholesterol is the first step for diagnosing patients with lipid metabolism disorders.

Heart attacks caused by acute myocardial infarction are the leading cause of death worldwide. The use of biomarkers that are able to diagnose acute myocardial infarction is essential. The coronary enzyme creatine kinase MB (CK-MB) is widely used to diagnose damaged cardiac tissue.