Protease portfolio: Selective Cleavage of Proteins

Achieve reproducible performance and high yields without risk of viral and microbial contamination in your final product. Our highly pure proteases are specifically designed for use as critical raw materials in the production of Active Pharmaceutical Ingredients (API), such as in insulin or vaccine production.

View entire protease portfolio

Recombinant Trypsin

Native Trypsin (EC has been used for many years in multiple applications. CustomBiotech has cloned trypsin into the yeast Pichia pastoris for recombinant gene expression and produced according to DIN EN ISO 13485. This procedure in fermentation and enzyme processing eliminates the risk of animal-derived material. No other proteases are used for downstream processing, making this product highly pure, extremely active, and free of any animal-derived material. Recombinant Trypsin is therefore ideal, even in regulated production environments.


Roche offers a wide selection of proteases that cleave peptides and proteins at the C- or N-terminal site of specific single amino acids. These proteases provide high lot-to-lot consistency and reproducibility, and are produced without animal components and according to DIN EN ISO 13485. Some of the endoproteinases are available as enzymes purified according to standard purification protocols or specifically designed purification protocols, making these enzymes particularly suitable for custom peptide mapping or proteomics applications. 


Protease inhibitors