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from Streptomyces species, lyophilizate

For further processing only.

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Order information
Pepstatin material number and pack size:
Material Number Pack Size
10253294103 custom fill
Will be supplied as "Pepstatin from Sreptomyces species". Unit of measure is "g".
Pepstatin is a protease inhibitor.
Pepstatin is a highly efficient inhibitor for many aspartic and acid proteases. It is a hexa-peptide containing the unusual amino acid statine (Sta, (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid), having the sequence Iva-Val-Val-Sta-Ala-Sta. Pepstatin is known for its ability to inhibit pepsin in a picomolar concentration. The product is soluble in methanol and ethanol, but insoluble in water.
Use Pepstatin to inhibit potently the HIV protease and other aspartic proteases such as pepsin, renin, cathepsin D, chymosin, and many microbial acid proteases.
Formula: C34H63N5O9
Molecular weight: 685.9 D
Pepstatin is soluble in methanol (1 mg/mL and 20 mg/mL as well) and ethanol (1 mg/ml) if you allowed to sit overnight, and to 300 μg/ml in 6 N acetic acid. Stable at least 1 week at +2 to +8°C or 1 month if stored in aliquots at -15 to -25°C.
Appearance: White powder
Clear to slightly opalescent, colorless solution in methanol (c=1 mg/mL)
Clear, colorless solution in methanol (c=20 mg/mL)
Clear to slightly opalescent, colorless solution in ethanol (overnight)
Performance of inhibition of pepsin:
With 0.01 mL sample: ≥85%
With 0.1 mL sample: ≥100%
Values are taken from supplier certificate:
Melting range: +232 to +237°C
Purity (HPLC): ≥98 area%
Stability: At +2 to +8°C within specification range for 24 months.