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Leupeptin

Ac-Leu-Leu-argininal x ½ H2SO4, synthetic

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Order information
Leupeptin material number and pack size:
Material Number Pack Size
10528595103 Minimum order quantity 200 mg,
custom fill
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Overview
Protease inhibitor of serine and cysteine proteases.
Leupeptin inhibits serine and thiol proteases such as trypsin, plasmin, proteinase K, kallikrein, papain, thrombin, and cathepsin A and B.
Not affected are α-, β-, γ- and δ- chymotrypsin, pepsin, cathepsin D, elastase, renin, and thermolysin.
Effective concentration 10-100 μM.
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Application
Leupeptin as well as other protease inhibitors like pepstatin are useful for the protection of proteins during their isolation from tissues or membranes. Leupeptin can be removed from the reaction by dialysis.
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Specification
Biological source: Synthetic
InChI Key: CIPMKIHUGVGQTG-VFFZMTJFSA-N
Assay: ≥96.5%
Form: powder
Molecular weight: D 475.6
Solubility(in H2O): 50 mg/mL
Storage temperature: +2 to +8°C
Formula: C20H38N6O4 × ½ H2SO4
Molar Mass: 475.6 g/mol
Appearance: White powder
Leupeptin (HPLC): 96.5 area %
Performance test (Inhibition of Trypsin; Inhibition exists): corresponds
Stability: At +2°C to +8°C: within specification range for 12 months; stored dry.