For further processing only. Others CMP-N-Acetylneuraminic Acid CMP-NANA CMP-N-Acetylneuraminic Acid (CMP-NANA) 78 1403506419168 The sale of the Product does not exhaust or grant any rights in third party patents including patents of companies of the F. Hoffmann - La Roche AG group of companies, in particular, for the use of modified antibodies obtained by using the product. 3.2.17.2.68.1 sodium salt, lyophilizate 05 974 003 103 5 974 003 103 05974003103 5974003103 05974003103 CMP-NANA, Sodium salt CMP-N-Acetylneuraminic Acid (CMP-NANA) Reagents, kits custom fill Not Available CustomBiotech product. Please contact your local representative. Will be supplied as "CMP-NANA, Sodium salt". Unit of measure is "kg". 1007117-62-5 en Incubation of CMP-NANA and α-2,6-Sialyltansferase or α-2,3-Sialyltansferase with a glycoprotein leads to increased sialylation of the glycoprotein. en CMP-NANA is a sodium salt, provided as a white, lyophilized substance. en Benefits of using in vitro glycoengineering to modify glycosylation of therapeutic proteins: Time- and cost-saving generation of glycan variants to develop improved drugs Optimized glycosylation without compromising other CQAs or product yield Improved lot-to-lot consistency to reduce risk of product quality variation and resulting delays Generation of glycoprofiles which may not otherwise be generated Streamlined analytics in comparability studies en CMP-N-Acetylneuraminic Acid is an activated sugar, and can be used for in vitro glycoengineering of glycoproteins, e.g. therapeutic proteins. en Appearance: White, lyophilized substance Solution (c = 100 mg/mL water): Clear, colorless CMP-NANA-Na2 (A260 ε=7.4 [L x mmol-1 x cm-1]): ≥87% CMP-NANA (HPLC): ≥90 area% CMP-NANA + CMP (HPLC): ≥95 area% Na (flame photometric): 6-8% Water (K. Fischer): ≤8% Heavy metals (as Pb): ≤25 ppm (in validation) CMP (HPLC): ≤10 area% CDP (HPLC): ≤1 area% CTP (HPLC): ≤0.5 area% Sialic acid (free and dehydrated): ≤10 area% Sum of unknown impurities (HPLC): ≤1 area% Bioburden: ≤100 CFU/g Stability: At -15 to -25°C within specification range for 24 months. en

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CMP-N-Acetylneuraminic Acid (CMP-NANA)

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