{ "ProductData": { "ID": "3.6.5.1.6.11", "ProductType": "Others", "BrandName": "NucleoMix (dUTP), PCR Grade", "ProductNameAddition": "sodium salt, 40 mM (10 mmol/L each dNTP)", "RegulatoryDisclaimer1": "For further processing only.", "DisclaimerGroup1": "", "RegulatoryDisclaimer2": null, "DisclaimerGroup2": null, "RegulatoryDisclaimer3": null, "SampleType": [ ], "LicenseDisclaimers": [ ], "RelatedLinks": "", "Clone": "", "ControlTissue": [ "" ], "ISOtypes": "", "Species": [ "" ], "StainLocalization": [ "" ], "ProductNameGlobal": "NucleoMix dUTP PCR Grade" }, "ProductImageDetails": { "ImagePath": "https://pim-media.roche.com/Images/CB_IMAGE.png", "ImageType": "Image main" }, "Product2Taxonomy": { "Product2TaxonomyReferences": [ { "StructureSystemIdentifier": "Product_Grouping", "StructureSystemName": "Product Grouping", "StructureNodeStatus": "valid", "NodeName": "Nucleotides", "NodeID": "02-0018" }, { "StructureSystemIdentifier": "OWP_Product_Types", "StructureSystemName": "Product Types", "StructureNodeStatus": "valid", "NodeName": "Deoxyucleotides", "NodeID": "70-015-00" }, { "StructureSystemIdentifier": "OWP_Organization", "StructureSystemName": "Organization", "StructureNodeStatus": "valid", "NodeName": "CustomBiotech and LifeScience", "NodeID": "01-01-01-07-00" }, { "StructureSystemIdentifier": "OWP_Family", "StructureSystemName": "Product Families", "StructureNodeStatus": "valid", "NodeName": "Nucleomix", "NodeID": "639" }, { "StructureSystemIdentifier": "Product_Grouping", "StructureSystemName": "Product Grouping", "StructureNodeStatus": "valid", "NodeName": "Molecular Raw Materials", "NodeID": "02-0136" }, { "StructureSystemIdentifier": "OWP_Techniques", "StructureSystemName": "Techniques", "StructureNodeStatus": "valid", "NodeName": "PCR/qPCR", "NodeID": "210-00" }, { "StructureSystemIdentifier": "OWP_Techniques", "StructureSystemName": "Techniques", "StructureNodeStatus": "valid", "NodeName": "RT-PCR/qRT-PCR", "NodeID": "300-00" }, { "StructureSystemIdentifier": "Product_Solutions", "StructureSystemName": "Product Solutions", "StructureNodeStatus": "valid", "NodeName": "CustomBiotech", "NodeID": "520" }, { "StructureSystemIdentifier": "Lab_Type", "StructureSystemName": "Lab Types", "StructureNodeStatus": "invalid", "NodeName": "", "NodeID": "180-00" }, { "StructureSystemIdentifier": "Applications", "StructureSystemName": "Applications", "StructureNodeStatus": "invalid", "NodeName": "", "NodeID": "99-00-00" }, { "StructureSystemIdentifier": "Disease_Areas", "StructureSystemName": "Disease Areas", "StructureNodeStatus": "invalid", "NodeName": "", "NodeID": "99-00-00" }, { "StructureSystemIdentifier": "Pathogens", "StructureSystemName": "Pathogens", "StructureNodeStatus": "invalid", "NodeName": "", "NodeID": "99-00-00" }, { "StructureSystemIdentifier": "Health_Topics", "StructureSystemName": "Health Topics", "StructureNodeStatus": "invalid", "NodeName": "", "NodeID": "99-00-00" } ] }, "Product2Materials": { "P2MaterialReferences": [ { "MaterialNum": "03186075103", "MaterialDescription": "Nucleomix(10 mmol/l,with dUTP)", "RegisteredProductName": "NucleoMix (dUTP), PCR Grade", "GTIN": "", "ProductCategoryText": "Reagents, kits", "OldMaterialNumber": "", "PackSizePIM360": "100 mL", "PackSizeDescPIM360": "Not Available", "MaterialAnnotation": "CustomBiotech product. Please contact your local representative.", "ReadyForUse": "", "OrderInformation": "Will be supplied as \"Nucleomix (10 mmol/L,with dUTP)\". Unit of measure is \"mL\"." } ] }, "Product2Products": { "Product2ProductReference": [ ] }, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Language": "en", "Value": "Will be supplied as \"Nucleomix (10 mmol/L,with dUTP)\". Unit of measure is \"mL\".", "Country": "XG", "Code": "CB - Order Information", "Name": "CB - Order Information" }, { "Language": "en", "Value": "NucleoMix (dUTP), PGR Grade, is supplied in sealed and CO₂-proof bottles to ensure a stable pH during shipment on dry ice. The manufacturing process is fully validated including the final filling step. The pH is adjusted to match conditions for amplification.", "Country": "XG", "Code": "Product Description", "Name": "Product Description" }, { "Language": "en", "Value": "NucleoMix (dUTP), PCR Grade, is designed for amplification reactions where high-quality reagents are required, such as for in vitro diagnostics. The ready-to-use mix eliminates process steps. Avoid carryover contamination between PCRs, a significant source of false positives. To decontaminate PCR and RT-PCR reagent mixes, dUTP is incorporated in place of dTTP. Subsequent reactions should be treated with Uracil-DNA Glycosylase (UNG) before amplification to degrade dUTP-containing PCR products.", "Country": "XG", "Code": "Applications", "Name": "Applications" }, { "Language": "en", "Value": "Manufactured under GMP (Good Manufacturing Practice) regulations.", "Country": "XG", "Code": "Quality Control", "Name": "Quality Control" }, { "Language": "en", "Value": "GMP-manufactured NucleoMixes from the leading manufacturer of nucleotides for outstanding, consistent performance in amplification reactions.", "Country": "XG", "Code": "Positioning", "Name": "Positioning" }, { "Language": "en", "Value": "Appearance: Clear, colorless solution
pH value: 8.1-8.5
Concentration (sum, 1 μmol ≙ 11.0 A₂₆₀ units, pH 7.0): 40-44 mmol/L
Identity (HPLC diode array detector):
dATP: 9-12 mmol/L
dCTP: 9-12 mmol/L
dGTP: 9-12 mmol/L
dUTP: 9-12 mmol/L
dNTP (HPLC, sum of 4 peaks): ≥99 area%
dNDP (HPLC, sum of 4 peaks): ≤0.9 area%
DNases/RNases: Negative
Nicking activity: Negative
Function test in PCR (RNA, human dystrophin gene): Corresponds to specification
Stability: At -15 to -25°C within specification range for 35 months.", "Country": "XG", "Code": "Specification", "Name": "Specification" } ] } } ] }