{ "ProductData": { "RelatedLinks": "", "RegulatoryDisclaimer1": "For further processing only.", "RegulatoryDisclaimer2": "", "StainLocalization": [ "" ], "ProductType": "Others", "DisclaimerGroup2": null, "ProductNameGlobal": "Neuraminidase exo-alpha-Sialidase", "DisclaimerGroup1": "Non-IVD", "ControlTissue": [ "" ], "BrandName": "Neuraminidase (exo-α-Sialidase)", "LicenseDisclaimers": [ { "Order": "78", "Identifier": "1403506419168", "LongText": "The sale of the Product does not exhaust or grant any rights in third party patents including patents of companies of the F. Hoffmann - La Roche AG group of companies, in particular, for the use of modified antibodies obtained by using the product." } ], "Isotypes": "", "RegulatoryDisclaimer3": "", "ID": "3.1.1.2.20.1", "ProductNameAddition": "from Vibrio cholerae, solution", "Species": [ "" ], "Clone": "" }, "ProductImageDetails": { "ImagePath": "https://pim-media.roche.com/Images/CB_IMAGE.png", "ImageType": "Image main" }, "Product2Taxomony": { "Product2TaxomonyReferences": [ { "StructureSystemIdentifier": "OWP_Product_Solutions", "StructureSystemName": "OWP Product Solutions", "NodeName": "CustomBiotech", "NodeID": "520" }, { "StructureSystemIdentifier": "OWP_Product_Types", "StructureSystemName": "OWP Product Types", "NodeName": "Raw Materials->Glycosidases", "NodeID": "70-024-00" }, { "StructureSystemIdentifier": "Product_Grouping", "StructureSystemName": "Product Grouping", "NodeName": "CustomBiotech->In vitro Glycoengineering", "NodeID": "02-0052" }, { "StructureSystemIdentifier": "OWP_Organization", "StructureSystemName": "OWP Organization", "NodeName": "Roche Diagnostics Solution (RDS)->Customer Areas->Core lab->CustomBiotech and LifeScience", "NodeID": "01-01-01-07-00" }, { "StructureSystemIdentifier": "Product_Grouping", "StructureSystemName": "Product Grouping", "NodeName": "CustomBiotech->Enzymes", "NodeID": "02-0014" }, { "StructureSystemIdentifier": "Product_Solutions", "StructureSystemName": "Product Solutions", "NodeName": "CustomBiotech", "NodeID": "520" } ] }, "Product2Materials": { "P2MaterialReferences": [ { "MaterialNum": "11087096103", "MaterialDescription": "Neuraminidase (Sialidase)", "RegisteredProductName": "Neuraminidase (exo-?-Sialidase)", "GTIN": "", "ProductCategoryText": "Reagents, kits", "OldMaterialNumber": "", "PackSizePIM360": "custom fill", "PackSizeDescPIM360": "", "MaterialAnnotation": "CustomBiotech product. Please contact your local representative.", "ReadyForUse": "", "OrderInformation": "Will be supplied as \"Neuraminidase (Sialidase)\". Unit of measure is \"U\"." } ] }, "Product2Products": { "Product2ProductReference": [ ] }, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Language": "en", "Value": "Neuraminidase hydrolyzes terminal N- or O-acetylneuraminic acids which are α2,3-, α2,6-, α2,8- linked to oligosaccharides, polysaccharides, mucopolysaccharides, glycoproteins, and glycolipids. For the hydrolysis of glycolipids, the presence of a detergent is necessary. Roche's Neuraminidase is very well suited for structural research studies on glycoconjugates and for hydrolytic cleavage of sialic acid from biological material.", "Name": "Applications" }, { "Language": "en", "Value": "Will be supplied as \"Neuraminidase (Sialidase)\". Unit of measure is \"U\".", "Name": "CB - Order Information" }, { "Language": "en", "Value": "Neuraminidase is a glycohydrolase.", "Name": "Positioning" }, { "Language": "en", "Value": "Neuraminidase hydrolyzes terminal N- or O-acyl-neuraminic acids that are α2,3-, α2,6-, or α2,8-linked to galactose, Hex, NAc, or N- or O-acylated neuraminyl residues in oligosaccharides/glycoconjugates or colominic acid. Relative rate of cleavage is α2→3 >α2→6 >α2→8, determined on bonds in tri- and tetrasaccharides.", "Name": "Product Description" }, { "Language": "en", "Value": "CAS Number: 9001-67-6
Molecular weight: Approximately 95 kD
pH optimum: 5.5-6.2
Specific activity: Approximately 20 U/mg total protein (approximately 40 U/mg enzyme protein at +37°C) and pH 5.5 with N-acetyl-neuraminosyl-D-lactose as the substrate.", "Name": "Properties" }, { "Language": "en", "Value": "Appearance: Clear, colorless solution
Contents (after blending with Micr-O-protect^® and EDTA): Natrium acetate, 50 mmol/L; NaCl, 154 mmol/L; CaCl₂, 9 mmol/L; EDTA, 10 mmol/L; Micr-O-protect^® 0.1% (w/v)
pH value: 5.0-6.0
Activity (+37°C, with N-acetylneuraminyl-lactose): ≥1.0 U/mL
Stability: At +2 to +8°C within specification range for 18 months.", "Name": "Specification" } ] } } ] }