{ "ProductData": { "RelatedLinks": "", "RegulatoryDisclaimer1": "For further processing only.", "RegulatoryDisclaimer2": "", "StainLocalization": [ "" ], "DisclaimerGroup2": null, "ProductNameGlobal": "N1-Methyl-Pseudo-UTP", "DisclaimerGroup1": "Other - Non IVD", "ControlTissue": [ "" ], "BrandName": "N¹-Methyl-Pseudo-UTP", "LicenseDisclaimers": [ ], "Isotypes": "", "RegulatoryDisclaimer3": "", "ID": "3.6.5.5.4.8", "ProductNameAddition": "sodium salt, 100 mM", "Species": [ "" ], "Clone": "" }, "ProductSpec": { "ProductSpecVariant": { "Chapters": [ { "Language": "English", "Value": "N¹-Methyl-Pseudo-UTP is supplied in sealed and CO₂-proof bottles to ensure a stable pH during shipment on dry ice. It is animal-origin-free (AOF).
The pH is adjusted to match conditions for in-vitro-transcription reactions. Two fill sizes (1 and 100 mL) address the needs of R&D and manufacturing.", "Name": "Product Description" }, { "Language": "English", "Value": "This modified UTP can replace UTP in in-vitro-transcription reactions, e.g. for manufacturing mRNA Therapeutics. This RNA modification provides enhanced protein expression and reduced unwanted immunogenicity against the mRNA molecule itself It has been shown to reduce the immunogenicity of mRNA and is used in Covid-19 vaccines.", "Name": "Applications" }, { "Language": "English", "Value": "Reduce efforts and risk in development and manufacturing of mRNA therapeutics by relying on this modified ribonucleotide from a high volume NTP supplier:

• Extended QC-release testing using validated procedures ensures the suitability for applications that demand a high lot-to-lot stability and the absence of activities that can reduce the yield of mRNA synthesis.
• A single-use concept and/or cleaning validation guarantee no cross contamination.

", "Name": "Benefits" }, { "Language": "English", "Value": "Appearance: Clear, colorless solution
pH value: 8.1–8.5
N¹-Methyl-Pseudo-UTP (A271; pH 7.0 ε= 7.3 [L x mmol–1 x cm–1]): 100–110 mmol/L
N¹-Methyl-Pseudo-UTP (HPLC): ≥ 97 area%
Identity (HPLC-MS): corresponds
DNases/RNases: Negative
Nicking activity: Negative
Functional transcription assay: Corresponds to specification
Proteases: not detectable
Exonucleases: not detectable
Endotoxins: ≤ 10 EU/mL
Bioburden: ≤ 10 CFU/mL
Heavy metals (Ni, Co, V): ≤ 10 ppm
Stability: At -15 to -25°C within specification range for 18 months from date of manufacture.", "Name": "Specification" } ] } }, "Product2Taxomony": { "Product2TaxomonyReferences": [ { "StructureSystemName": "OWP Product Solutions", "NodeName": "CustomBiotech", "StructureSystemID": null, "NodeID": "520" }, { "StructureSystemName": "OWP Product Types", "NodeName": "Raw Materials and Reagents->Labeled Nucleotides", "StructureSystemID": null, "NodeID": "70-030-00" }, { "StructureSystemName": "Product Grouping", "NodeName": "CustomBiotech->mRNA Reagents", "StructureSystemID": null, "NodeID": "02-0062" }, { "StructureSystemName": "OWP Organization", "NodeName": "Roche Diagnostics Solution (RDS)->Customer Areas->Core lab->CustomBiotech and LifeScience", "StructureSystemID": null, "NodeID": "01-01-01-07-00" }, { "StructureSystemName": "Product Grouping", "NodeName": "CustomBiotech->Molecular Raw Materials", "StructureSystemID": null, "NodeID": "02-0136" }, { "StructureSystemName": "Product Grouping", "NodeName": "CustomBiotech->Nucleotides", "StructureSystemID": null, "NodeID": "02-0018" } ] }, "Product2Materials": { "P2MaterialReferences": [ { "MaterialNum": "09522409103", "MaterialDescription": "N1-Methyl-Pseudo-UTP, Na salt 100mM, 1mL", "RegisteredProductName": "", "GTIN": "", "ProductCategoryText": "Reagents, kits", "OldMaterialNumber": "", "PackSizePIM360": "1.0 mL", "PackSizeDescPIM360": "", "MaterialAnnotation": "", "ReadyForUse": "", "OrderInformation": "Will be supplied as \"N1-Methyl-Pseudo-UTP, Na salt, 100 mM, 1 mL\". Unit of measure is \"piece\"." }, { "MaterialNum": "09188991103", "MaterialDescription": "N1-Methyl-Pseudo-UTP, Na salt, 100 mM", "RegisteredProductName": "", "GTIN": "", "ProductCategoryText": "Reagents, kits", "OldMaterialNumber": "", "PackSizePIM360": "100 mL", "PackSizeDescPIM360": "", "MaterialAnnotation": "", "ReadyForUse": "", "OrderInformation": "Will be supplied as \"N1-Methyl-Pseudo-UTP, Na salt, 100 mM\". Unit of measure is \"mL\"." } ] }, "Product2Products": { "Product2ProductReference": [ ] } }