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"Product Grouping", "StructureNodeID": "02-0090", "StructureGroupPath": "CustomBiotech->Vaccine Testing", "StructureGroupName": "Vaccine Testing" } ] } ] }, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Language": "en", "Value": "Modified UTP for the use in mRNA synthesis.", "Name": "Positioning" }, { "Language": "en", "Value": "Substituting UTP used for in vitro transcription reactions, this modified UTP generates a modified RNA with enhanced protein expression and reduced unwanted immunogenicity against the mRNA molecule itself. Its efficacy has been provenin the manufacture of COVID-19 vaccines.", "Name": "Applications" }, { "Language": "en", "Value": "Use this modified UTP in the synthesis of mRNA for therapeutics or vaccines. It is designed to meet the specific needs of the pharmaceutical industry (fit-for-purpose):

• animal-origin-free (AOF)
• free of ß-Lactam-antibiotics
• extended testing for impurities
• validated QC release methods and cleaning validation
• supplied with supplementary documents for regulatory submissions.

", "Name": "Benefits" }, { "Language": "en", "Value": "Nomenclature: N¹-methyl-pseudouridine-5'-triphosphate
CAS Number: 1428903-59-6 (free acid)
Formula: C₁₀H₁₇N₂O₁₅P₃ (free acid)
Molecular weight: 498.2 D (free acid)", "Name": "Properties" }, { "Language": "en", "Value": "Appearance: Clear, colorless solution
pH value: 8.1–8.5
N¹-Methyl-Pseudo-UTP (A271; pH 7.0 ε= 7.3 [L x mmol–1 x cm–1]): 100–110 mmol/L
N¹-Methyl-Pseudo-UTP (HPLC): ≥ 97 area%
Identity (HPLC-MS): corresponds
DNases/RNases: Negative
Nicking activity: Negative
Functional transcription assay: Corresponds to specification
Proteases: not detectable
Exonucleases: not detectable
Endotoxins: ≤ 10 EU/mL
Bioburden: ≤ 10 CFU/mL
Heavy metals (Ni, Co, V): ≤ 10 ppm
Stability: At -15 to -25°C within specification range for 12 months.", "Name": "Specification" }, { "Language": "en", "Value": "Mat. no. 09188991103 will be supplied as \"N1-Methyl-Pseudo-UTP, Na salt, 100 mM\". Unit of measure is \"mL\".
Mat. no. 09522409103 will be supplied as \"N1-Methyl-Pseudo-UTP, Na salt, 100 mM, 1 mL\". Unit of measure is \"piece\".
 ", "Name": "CB - Order Information" }, { "Language": "en", "Value": "Manufactured under ISO 134485:2016. QC-release makes use of an extended range of validated methods.", "Name": "Quality Control" } ] } } ] }