You appear to be using incognito/private browsing mode or an ad blocker, which may adversely affect your experience on the site. Please disable any ad blockers and view the site in non-private mode.
{
"ProductData": {
"RelatedLinks": "",
"RegulatoryDisclaimer1": "For further processing only.",
"RegulatoryDisclaimer2": "",
"StainLocalization": [
""
],
"ProductType": "Others",
"DisclaimerGroup2": null,
"ProductNameGlobal": "N1-Methyl-Pseudo-UTP",
"DisclaimerGroup1": "Non-IVD",
"ControlTissue": [
""
],
"BrandName": "N1-Methyl-Pseudo-UTP",
"LicenseDisclaimers": [
],
"Isotypes": "",
"RegulatoryDisclaimer3": "",
"ID": "3.6.5.5.4.8",
"ProductNameAddition": "sodium salt, 100 mM",
"Species": [
""
],
"Clone": ""
},
"ProductImageDetails": {
"ImagePath": null,
"ImageType": "Image main"
},
"Product2Taxomony": {
"Product2TaxomonyReferences": [
{
"StructureSystemIdentifier": "OWP_Product_Solutions",
"StructureSystemName": "OWP Product Solutions",
"NodeName": "CustomBiotech",
"NodeID": "520"
},
{
"StructureSystemIdentifier": "OWP_Product_Types",
"StructureSystemName": "OWP Product Types",
"NodeName": "Raw Materials->Labeled Nucleotides",
"NodeID": "70-030-00"
},
{
"StructureSystemIdentifier": "Product_Grouping",
"StructureSystemName": "Product Grouping",
"NodeName": "CustomBiotech->mRNA Reagents",
"NodeID": "02-0062"
},
{
"StructureSystemIdentifier": "OWP_Organization",
"StructureSystemName": "OWP Organization",
"NodeName": "Roche Diagnostics Solution (RDS)->Customer Areas->Core lab->CustomBiotech and LifeScience",
"NodeID": "01-01-01-07-00"
},
{
"StructureSystemIdentifier": "Product_Grouping",
"StructureSystemName": "Product Grouping",
"NodeName": "CustomBiotech->Molecular Raw Materials",
"NodeID": "02-0136"
},
{
"StructureSystemIdentifier": "Product_Grouping",
"StructureSystemName": "Product Grouping",
"NodeName": "CustomBiotech->Nucleotides",
"NodeID": "02-0018"
},
{
"StructureSystemIdentifier": "Product_Solutions",
"StructureSystemName": "Product Solutions",
"NodeName": "CustomBiotech",
"NodeID": "520"
}
]
},
"Product2Materials": {
"P2MaterialReferences": [
{
"MaterialNum": "09522409103",
"MaterialDescription": "N1-Methyl-Pseudo-UTP, Na salt 100mM, 1mL",
"RegisteredProductName": "N1-Methyl-Pseudo-UTP",
"GTIN": "",
"ProductCategoryText": "Reagents, kits",
"OldMaterialNumber": "",
"PackSizePIM360": "1.0 mL",
"PackSizeDescPIM360": "",
"MaterialAnnotation": "",
"ReadyForUse": "",
"OrderInformation": "Will be supplied as \"N1-Methyl-Pseudo-UTP, Na salt, 100 mM, 1 mL\". Unit of measure is \"piece\"."
},
{
"MaterialNum": "09188991103",
"MaterialDescription": "N1-Methyl-Pseudo-UTP, Na salt, 100 mM",
"RegisteredProductName": "N1-Methyl-Pseudo-UTP",
"GTIN": "",
"ProductCategoryText": "Reagents, kits",
"OldMaterialNumber": "",
"PackSizePIM360": "100 mL",
"PackSizeDescPIM360": "",
"MaterialAnnotation": "",
"ReadyForUse": "",
"OrderInformation": "Will be supplied as \"N1-Methyl-Pseudo-UTP, Na salt, 100 mM\". Unit of measure is \"mL\"."
}
]
},
"Product2Products": {
"Product2ProductReference": [
]
},
"ProductSpec": [
{
"ProductSpecVariant": {
"Chapters": [
{
"Language": "en",
"Value": "Modified UTP for the use in mRNA synthesis.",
"Name": "Positioning"
},
{
"Language": "en",
"Value": "N1-Methyl-Pseudo-UTP is supplied in sealed and CO2-proof bottles to ensure a stable pH during shipment on dry ice. It is animal-origin-free (AOF). The pH is adjusted to match conditions for in-vitro-transcription reactions. Two fill sizes (1 and 100 mL) address the needs of R&D and manufacturing.",
"Name": "Product Description"
},
{
"Language": "en",
"Value": "This modified UTP can replace UTP in in-vitro-transcription reactions, e.g. for manufacturing mRNA Therapeutics. This RNA modification provides enhanced protein expression and reduced unwanted immunogenicity against the mRNA molecule itself It has been shown to reduce the immunogenicity of mRNA and is used in Covid-19 vaccines.",
"Name": "Applications"
},
{
"Language": "en",
"Value": "Reduce efforts and risk in development and manufacturing of mRNA therapeutics by relying on this modified ribonucleotide from a high volume NTP supplier:
Extended QC-release testing using validated procedures ensures the suitability for applications that demand a high lot-to-lot stability and the absence of activities that can reduce the yield of mRNA synthesis.
A single-use concept and/or cleaning validation guarantee no cross contamination.
",
"Name": "Benefits"
},
{
"Language": "en",
"Value": "Nomenclature: N1-methyl-pseudouridine-5'-triphosphate Formula: C10H17N2O15P3 Molecular weight: 498.2 D",
"Name": "Properties"
},
{
"Language": "en",
"Value": "Appearance: Clear, colorless solution pH value: 8.1–8.5 N1-Methyl-Pseudo-UTP (A271; pH 7.0 ε= 7.3 [L x mmol–1 x cm–1]): 100–110 mmol/L N1-Methyl-Pseudo-UTP (HPLC): ≥ 97 area% Identity (HPLC-MS): corresponds DNases/RNases: Negative Nicking activity: Negative Functional transcription assay: Corresponds to specification Proteases: not detectable Exonucleases: not detectable Endotoxins: ≤ 10 EU/mL Bioburden: ≤ 10 CFU/mL Heavy metals (Ni, Co, V): ≤ 10 ppm Stability: At -15 to -25°C within specification range for 18 months from date of manufacture.",
"Name": "Specification"
},
{
"Language": "en",
"Value": "Mat. no. 09188991103 will be supplied as \"N1-Methyl-Pseudo-UTP, Na salt, 100 mM\". Unit of measure is \"mL\". Mat. no. 09522409103 will be supplied as \"N1-Methyl-Pseudo-UTP, Na salt, 100 mM, 1 mL\". Unit of measure is \"piece\". ",
"Name": "CB - Order Information"
},
{
"Language": "en",
"Value": "Manufactured under ISO 134485:2016. QC-release makes use of an extended range of validated methods.",
"Name": "Quality Control"
}
]
}
}
]
}
