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Please contact your local representative.", "ReadyForUse": "", "OrderInformation": "Will be supplied as \"MDH, IFCC-quality, Pig Heart (Mitochon.)\". Unit of measure is \"MU\"." } ] }, "Product2Products": { "Product2ProductReference": [ ] }, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Language": "en", "Value": "Will be supplied as \"MDH, IFCC-quality, Pig Heart (Mitochon.)\". Unit of measure is \"MU\".", "Country": "XG", "Code": "CB - Order Information", "Name": "CB - Order Information" }, { "Language": "en", "Value": "Use Malate Dehydrogenase in diagnostic tests for the determination of aspartate aminotransferase or in applications for citric and acetic acid testing.", "Country": "XG", "Code": "Applications", "Name": "Applications" }, { "Language": "en", "Value": "Dehydrogenase that catalyzes the interconversion of malate to oxaloacetate.", "Country": "XG", "Code": "Positioning", "Name": "Positioning" }, { "Language": "en", "Value": "Appearance: Clear, colorless solution in glycerol (50% (v/v))
pH value: 6.5-7.5
Specific activity (+30°C, oxaloacetate): ≥900 U/mg protein
Protein (Biuret): ≥10 mg/mL
Contaminants (expressed as percentage of Malate Dehydrogenase activity):
Aspartate aminotransferase (AST/GOT): ≤0.005
Alanine aminotransferase (ALT/GPT): ≤0.005
Glutamate dehydrogenase: ≤0.003
Reagent blank for determination of aspartate aminotransferase (AST/GOT): ≤0.009 (A334/10 minutes)
SVD free: Corresponds to specification
pH 5.5 treatment (for at minimum 30 minutes): Corresponds to specification
Stability: At +2 to +8°C within specification range for 12 months.", "Country": "XG", "Code": "Specification", "Name": "Specification" }, { "Language": "en", "Value": "Nomenclature: L-malate:NAD+ oxidoreductase
CAS Number: 9001-64-3
Molecular weight: 70 kD
Isoelectric point: 6.1-6.4
Michaelis constants (Phosphate buffer, 95 mmol/L, pH 8.3, +25°C):
L-malate: 4.0 x 10-4 mol/L
L-tartrate: 9.0 x 10-3 mol/L
meso-tartrate: 1.2 x 10-3 mol/L
oxaloacetate: 3.3 x 10-5 mol/L
Inhibitors: Iodinated compounds such as iodine cyanide, thyroxine and molecular iodine, phenols, 1,10-phenanthroline, 8-hydroxyquinoline, sulfide, nicotinic acidamide, adenine, AMP, ATP; oxaloacetate (excess).
Activators: Phosphate, arsenate, Zn2+
pH optimum: 7.5 (see figure)
Temperature dependence: See figure
pH stability: 7.0-9.0 (see figure)
Thermal stability: Up to +40°C (see figure)
Specificity: L-configuration of malate and tartrate. NAD can be replaced by its analogs, but not by NADP.", "Country": "XG", "Code": "Properties", "Name": "Properties" } ] } } ] }

Malate Dehydrogenase, IFCC Quality

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