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After first use on the instrument, the reagent cassette is stable for up to 12 weeks on board.

", "Name": "Storage Conditions (Working Solution)" }, { "Language": "en", "Value": "Store the reagent cassette at +2 to +8°C.", "Name": "Storage Conditions (Product)" }, { "Language": "en", "Value": "
Analyzer and accessories
  • Cedex Bio HT Analyzer*, including accessories and disposables
  • Standard laboratory equipment
Calibrators and Controls
  • Calibrator B Bio*
  • Control B Level 1 Bio*
  • Control B Level 2 Bio*
  • Control B Level 3 Bio*
", "Name": "Additional Equipment and Reagent Required" }, { "Language": "en", "Value": "Unit of measure is \"piece\".", "Name": "CB - Order Information" }, { "Language": "en", "Value": "Kit for determination of lactate dehydrogenase activity.", "Name": "Product Description" }, { "Language": "en", "Value": "Application LDH2B (959), LDH2D (721)
Cedex Bio HT test definiton:
  • Measuring mode\t\t\t\t  Absorbance
  • Abs. calculation mode\t\t Kinetic
  • Reaction mode\t\t\t\t\t  R1-S-SR
  • Reaction direction\t\t\t\tIncrease
  • Wavelength A/B\t\t\t\t\t340/659 nm
  • Calc. first/last\t\t\t\t\t\t48/64
  • Unit\t\t\t\t\t\t\t\t\t\t  U/L

Pipetting parameters:
  • R1\t\t\t\t\t\t\t\t\t\t   100 μL
  • Sample\t\t\t\t\t\t\t\t  4 μL+ 4 μL Diluent (H2O)
  • SR (R2)\t\t\t\t\t\t\t\t  20 μL+ 10 μL Diluent (H2O)
  • Total volume\t\t\t\t\t\t138 μL

Calibration:
  • Calibrator\t\t\t\t\t\t\t  Calibrator B Bio (CAL B, 07-1105-5)
  • Calibration mode\t\t\t\tLinear regression
  • Calibration interval\t\t\t  Each new lot, and if recalibration is required due to QC results

Quality control:
  • Control B Level 1 Bio (CONB1, 07-1106-3)
  • Control B Level 2 Bio (CONB2, 07-1107-1)
  • Control B Level 3 Bio (CONB3, 07-1109-8)

Use the recommended control material. Other suitable control material can be used in addition.
Control intervals and acceptance limits should be adapted to each laboratory's individual requirements.
If values do not fall within the defined limits, corrective measures and recalibration are required", "Name": "Protocols - Help Corner" }, { "Language": "en", "Value": "
VialContentComposition
LDH2BReagent cassette,
300 tests
Reagent 1 (R1): N-methyl-D-glucamine, 400 mmol/L; lithium lactate, 62 mmol/L; stabilizer; preservative; pH (+37°C) 9.4.
Start Reagent (SR): Nicotinamide adenine dinucleotide, 62 mmol/L; stabilizer, preservative.
", "Name": "Content" }, { "Language": "en", "Value": "LDH activity can be determined in following ranges:
•LDH2B: 20 - 1000 U/L (0.334 - 16.7 μkat/L)
•LDH2D: 200 - 10000 U/L (3.34 - 167 μkat/L),
up to 100 U/L (1.67 μkat/L) with automatic dilution

Conversion Factors
Conversion factors for LDL activity:
  • 1 U/L = 0.0167 μkat/L
  • 1 μkat/L = 59.9 U/L

Traceability
This method has been standardized against a standard formulation of the IFCC (1994).

Precision
Representative performance data on Cedex Bio HT Analyzers are shown. Results obtained in individual laboratories may differ.
Precision was determined in samples of two concentration levels.
Coefficients of variation (CV) were calculated for in-run precision (n=21) and inter-run precision (on 21 days).

 Level 1Level 2
Mean155U/L\t\t   246U/L\t\t  
CV in-run1.0%0.6%
CV inter-run\t\t1.1%1.1%
", "Name": "Background Information - Help Corner" }, { "Language": "en", "Value": "Rising enzymatic activity of lactate dehydrogenase (LDH) in a cell culture supernatant is a distinct marker for increasing cell degradation, causing release of LDH from the cytosol into the medium. For monitoring in a culture process, LDH can be determined on a Cedex Bio or Cedex Bio HT Analyzer with high reliability and convenience.", "Name": "Applications" }, { "Language": "en", "Value": "Method: Enzymatic photometric assay using oxidation of lactate to pyruvate (acc. IFCC).
Recovery: ±10%", "Name": "Specification" } ] } } ] }

LDH Bio HT

Test kit for the Cedex Bio HT Analyzer

Cedex LDH

Overview

Ordering

Technical documents

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