For further processing into medical devices, IVD and pharmaceutical products only. Others GTP 100 mM pH 8.3 GMP Grade AOF GTP, GMP Grade, AOF 102 1584029687338397 Warranty LimitationIt is the sole responsibility of the customer to determine the suitability of all raw materials, products and components in order to ensure that the final end-use product is safe for its end use; performs or functions as intended; and complies with all applicable legal and regulatory requirements. Roche makes no representations or warranties of any kind regarding the Product, express or implied, other than those expressly set forth in the terms and conditions of sale (if any), and disclaims all implied or statutory warranties including warranty of merchantability and fitness for a particular purpose. PID00000723 100 mM, pH 8.3 09 745 203 103 9 745 203 103 09745203103 9745203103 09745203103 GTP, 100 mM pH 8.3, GMP Grade AOF, 500mL GTP, 100 mM pH 8.3, GMP Grade AOF, 500mL Reagents, kits 500 mL Not Available CustomBiotech product. Please contact your local representative. Unit of measure is "mL". Will be supplied as "GTP, GMP Grade, AOF, 500mL, 100 mM, pH 8.3". Minimum order quantity: 2000 mL 09 745 173 103 9 745 173 103 09745173103 9745173103 09745173103 GTP, 100 mM pH 8.3, GMP Grade AOF, 100mL GTP, 100 mM pH 8.3, GMP Grade AOF, 100mL Reagents, kits 100 mL Not Available CustomBiotech product. Please contact your local representative. Unit of measure is "mL". Will be supplied as "GTP, GMP Grade, AOF, 100mL, 100 mM, pH 8.3". Minimum order quantity: 100 mL 86-01-1 (free acid) en Fit for purpose GMP Grade qualityAnimal-Origin-Free process (AOF)Antibiotics-free processExtended testing for impuritiesTesting of Heavy Metals as contaminantRegulatory document support en NTPs are the critical starting materials of in vitro mRNA synthesis for therapeutics or vaccines. en Appearance: Clear, colorless solution pH value: 8.1-8.5 (25 °C ± 1 °C) GTP (A252; pH 7.0 ε = 13.7 [L x mmol-1 x cm-1]): 100-110 mmol/L GTP (HPLC): ≥ 98.5 area% GDP (HPLC): ≤ 1.5 area% GMP (HPLC): ≤ 0.5 area% Sum from GTP + GDP + GMP (HPLC): ≥ 99.5 area% Heavy metals (sum from V, Ni with ICP-MS): ≤ 10 ppm Proteases (recovery Aldolase ≥ 80%): Corresponds to specification Bioburden (TAMC): ≤ 5 CFU/ml Endotoxins: ≤ 2 EU/ml DNases/RNases: Negative Nicking activity: Negative Functional transcription assay: Corresponds to specification Identity HPLC-MS: Corresponds to specification Stability: At -15 to -25°C within specification range for 18 months from date of manufacture. en Together with CTP, ATP, UTP and/or modified UTP, GTP is part of the ribonucleotide mix needed to synthesize mRNA in the presence of a RNA polymerase. en GTP is produced using a sustainable, non-chemical process. In contrast to a chemical synthesis, this process avoids heavy metal catalysed processes. The production is completely animal origin free. To comply with regulatory requirements, it produced under GMP The manufacturing process is validated including the final filling step, followed by QC-release testing. The pH is adjusted to match conditions for in vitro transcription. To ensures you a stable pH during shipment on dry ice and constant product quality, the solution is supplied in sealed and CO2-proof bottles. en

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