rdoe_global.search
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"NameofStructureSystem": "Product Families", "StructureNodeID": "999", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "invalid" }, { "IdentifierofStructureSystem": "Health_Topics", "NameofStructureSystem": "Health Topics", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "invalid" }, { "IdentifierofStructureSystem": "Product_Grouping", "NameofStructureSystem": "Product Grouping", "StructureNodeID": "02-0090", "StructureGroupPath": "CustomBiotech->Vaccine Testing", "StructureGroupName": "Vaccine Testing", "StructureNodeStatus": "valid" }, { "IdentifierofStructureSystem": "Product_Grouping", "NameofStructureSystem": "Product Grouping", "StructureNodeID": "02-0133", "StructureGroupPath": "CustomBiotech->Cell and Gene Therapy", "StructureGroupName": "Cell and Gene Therapy", "StructureNodeStatus": "valid" } ] } ] }, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Language": "en", "Value": "GTP is produced enzymatically, a virus filtration concludes the synthesis, a TSE/BSE statement is available. To comply with regulatory requirements, it produced under GMP, the manufacturing process is fully validated including the final filling step, followed by QC-release testing. The pH is adjusted to match conditions for in vitro transcription, the solution is supplied in sealed and CO2-proof bottles to ensure a stable pH during shipment on dry ice.", "Country": "XG", "Code": "Product Description", "Name": "Product Description" }, { "Language": "en", "Value": "Together with ATP, CTP, UTP and/or modified UTP, GTP is part of the ribonucleotide mix needed to synthesize mRNA in the presence of a RNA polymerase.", "Country": "XG", "Code": "Applications", "Name": "Applications" }, { "Language": "en", "Value": "Will be supplied as \"GTP GMP Grade, 100 mmol/L, 100 mL\". Unit of measure is \"mL\".", "Country": "XG", "Code": "CB - Order Information", "Name": "CB - Order Information" }, { "Language": "en", "Value": "NTPs are the critical starting materials of in vitro mRNA synthesis for therapeutics or vaccines.", "Country": "XG", "Code": "Positioning", "Name": "Positioning" }, { "Language": "en", "Value": "Avoid to change reagents or supplier when using this NTP GMP Grade from R&D to commercialization phase, allowing a smooth transition from lab scale to industrial production scale.", "Country": "XG", "Code": "Benefits", "Name": "Benefits" }, { "Language": "en", "Value": "Manufactured under GMP (Good Manufacturing Practice) regulations.", "Country": "XG", "Code": "Quality Control", "Name": "Quality Control" }, { "Language": "en", "Value": "Nomenclature: Guanosine-5'-triphosphate
CAS Number: 86-01-1 (free acid)
Formula: C10H16N5O14P3 (free acid)
Molecular weight: 523.2 D (free acid)", "Country": "XG", "Code": "Properties", "Name": "Properties" }, { "Language": "en", "Value": "Appearance: Clear, colorless solution
pH value: 8.1-8.5
GTP (A 252; pH 7.0 ε = 13.7 [L x mmol-1 x cm-1]: 100-110 mmol/L
GTP (HPLC): ≥98 area%
GDP (HPLC): ≤1.5 area%
GMP (HPLC): ≤0.5 area%
Qualification for molecular biology: Corresponds to specification
DNases/RNases: Negative
Nicking activity: Negative
Functional transcription assay: Corresponds to specification
Stability: At -15 to -25°C within specification range for 30 months from date of manufacture.", "Country": "XG", "Code": "Specification", "Name": "Specification" } ] } } ] }

GTP, GMP Grade

sodium salt, 100 mM

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mrna

A solid start in mRNA synthesis
 

Ribonucleotides are the critical starting materials for the synthesis of mRNA by in vitro transcription.

Minimize risk and complications in the transition from development to industrial production of mRNA therapeutics or vaccines by relying on the same product quality from a high-volume NTP supplier:

* Consistent NTP production under GMP since 25 years.

* Obtain all natural NTPs and N1-Methyl-Pseudo-UTP from a single source.

Produced using validated manufacturing and cleaning processes up to the final filling step and released under stringent final QC checks. Know that you are getting consistent quality every time.

We work with you to provide the necessary technical documents for your regulatory submissions.

Changing reagent quality between pre-clinical development and commercialization poses a risk. Secure your processes by using the best available quality from the start.

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Technical documents

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for certificates, method sheets (instructions for use), safety data sheets and software downloads
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SP6 RNA Polymerase, rec., AOF from SP6 bacteriophage, recombinant in E.coli, solution
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N1-Methyl-Pseudo-UTP, GMP Grade, AOF sodium salt, 100 mM, solution A clean start in mRNA synthesis: Partially or completely replace UTP with this modified UTP to enhance the performance of modified mRNA. Discover this fit-for-purpose reagent to manufacture mRNA for therapeutics and vaccines.
pyrophosphatase
Pyrophosphatase, rec., GMP Grade, AOF from yeast, expressed in E. coli, solution Improve your yield of mRNA with this essential enzyme for in vitro transcription of mRNA. Discover fit-for-purpose reagents for mRNA therapeutics from CustomBiotech.
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ATP, GMP Grade sodium salt, 100 mM
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DNase I, rec., RNase-free, GMP Grade from bovine pancreas, expressed in Pichia pastoris, solution
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T7 RNA Polymerase, rec., GMP Grade, AOF from T7 bacteriophage, recombinant in E.coli, solution Designed fit-for-purpose to manufacture therapeutic mRNA Roche T7 RNA Polymerase provides versatility in your choice of nucleotides. Available in scale and quality from development to manufacturing. Learn more.
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RNase Inhibitor, rec., GMP Grade, AOF from rat lung, expressed in E. coli, solution Protect (m)RNA: RNase Inhibitor is essential whenever RNA needs protection from ubiquitous RNases. Discover this fit-for-purpose reagent to manufacture mRNA for therapeutics and vaccines.
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Restriction endonuclease Xba I, recombinant, AOF from Xanthomonas campestris pv. Badrii, expressed in E. coli, solution High quality template for mRNA synthesis. Antibiotic-free and Animal-Origin-Free (AOF)the quality, scale and performance you need for manufacturing templates for mRNA therapeutics and vaccines.
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CTP, GMP Grade sodium salt, 100 mM
Pseudo-UTP, AOF
Pseudo-UTP, AOF sodium salt, 100 mM, solution Partially or completely replace UTP with this modified UTP to enhance the performance of modified mRNA - a fit-for-purpose reagent to manufacture mRNA for therapeutics and vaccines.
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UTP, GMP Grade sodium salt, 100 mM
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