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"Health_Topics", "NameofStructureSystem": "Health Topics", "StructureNodeID": "99-00-00", "StructureGroupPath": "NOT APPLICABLE", "StructureGroupName": "NOT APPLICABLE" } ] } ] }, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Language": "en", "Value": "Store the reagent at +2 to +8°C.", "Name": "Storage Conditions (Product)" }, { "Language": "en", "Value": "Keep at +2 to +10°C for on-board use.
On-board stability: After first use on the instrument, the reagent is stable for up to 4 weeks.", "Name": "Storage Conditions (Working Solution)" }, { "Language": "en", "Value": "Glycerol concentration can be determined in following range

• GLYB: 9.21 to 921 mg/L (0.1 to 10 mmol/L)
• GLYD: 92.1 to 9210 mg/L (1 to 100 mmol/L)

up to 92 g/L (1 mol/L) with postdilution

Conversion factors for cholesterol concentration

• 1 mmol/L = 92.09 mg/L
• 1 mg/L = 10.86 μmol/L

Traceability
This method has been standardized against isotope dilution mass spectrometry (ID-MS).

Precision
Representative performance data on Cedex Bio Analyzers are shown. Results obtained in individual laboratories may differ.
Precision was determined in samples of three concentration levels. Coefficients of variation (CV) were calculated for in-run precision (n=21) and inter-run precision (on 10 days).

	Level 1	Level 2	Level 3
Mean	1.36 mmol/L (125 mg/L)	2.34 mmol/L (216 mg/L)	5.94 mmol//L (547 mg/L)
CV in-run	0.6%	0.8%	0.8%
CV inter-run	1.6%	1.7%	2.6%

", "Name": "Background Information - Help Corner" }, { "Language": "en", "Value": "This product is intended for quantitative determination of glycerol in aqueous solutions using the Cedex Bio Instrument.", "Name": "Product Description" }, { "Language": "en", "Value": "GLYB is the standard protocol for glycerol determination. If the glycerol concentration of samples is higher than 10 mmol/L (921 mg/L), protocol GLYD should be used (same protocol with preset 1:10 sample predilution).
Results higher than the valid measuring range will be flagged and a rerun with an automatic 1:10 predilution will be recommended by the software.


Cedex Bio test definition
Measuring mode                     Absorbance
Abs. calculation mode            Endpoint
Reaction direction                   Increase
Wavelength A/B                        512/659 nm
Calc. first/last                           6/21
Unit                                             mmol/L
Reaction mode                        R1-S

Pipetting parameters
R1                                               120 μl
Sample                                      2 μl + 28 μl Diluent (H2O)
Total volume                            150 μl

Calibration
Calibrator                                  Calibrator A Bio (CAL A, 599)
Calibration mode                    Linear regression
Calibration interval                  Each new lot, and if recalibration is required due to QC results


Quality controls
Control A Level 1 Bio (CONA1, 111)
Control A Level 2 Bio (CONA2, 112)
Control A Level 3 Bio (CONA3, 113)


Use the recommended control material. Other suitable control material can be used in addition.

Control intervals and acceptance limits should be adapted to each laboratory's individual requirements.
If values do not fall within the defined limits, corrective measures and recalibration are required", "Name": "Protocols - Help Corner" }, { "Language": "en", "Value": "Unit of measure is \"piece\".", "Name": "CB - Order Information" }, { "Language": "en", "Value": "

Vial	Cap	Content	Composition
1 GLYB R1	white	4 vials, 50 tests each	Reagent 1 (R1): PIPES, 50 mmol/L, pH 6.8; glycerol kinase, ≥175 U/L; glycerol-3-phosphate oxidase, ≥2.5 kU/L; horseradish peroxidase, ≥100 U/L; adenosine triphosphate,1.4 mmol/L; 4-aminoantipyrine, 0.13 mmol/L; 4-chlorophenol, 4.7 mmol/L; sodium cholate, 0.2 mmol/L; non-reactive surfactant; preservative.

", "Name": "Content" }, { "Language": "en", "Value": "

• Cedex Bio Analyzer*, including accessories and disposables
• Standard laboratory equipment

• Calibrator A Bio*
• Control A Level 1 Bio*
• Control A Level 2 Bio*
• Control A Level 3 Bio*

", "Name": "Additional Equipment and Reagent Required" }, { "Language": "en", "Value": "Glycerol can be used as source of carbon and energy in microbial fermentation. In order to provide sufficient supply and to avoid inhibition by high concentrations, the optimal feeding with glycerol should be according to the actual consumption. For control of culture media and for monitoring in a culture process, the glycerol concentration can be determined on a Cedex Bio or Cedex Bio HT Analyzer with high reliability and convenience.", "Name": "Applications" }, { "Language": "en", "Value": "Method: Enzymatic photometric assay using glycerol kinase and glycerol-3-phosphate oxidase.
Recovery: ±10%", "Name": "Specification" } ] } } ] }