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"BrandName": "Cholesterol Esterase, Grade I",
"ProductNameAddition": "from
Pseudomonas species, lyophilizate",
"RegulatoryDisclaimer1": null,
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"RegulatoryDisclaimer2": null,
"DisclaimerGroup2": null,
"RegulatoryDisclaimer3": "For customers in the European Economic Area: Contains SVHC: octyl/nonylphenol ethoxylates. For further processing on its own or in a mixture as part of an IVD method and under controlled conditions only – acc. to Art. 56 (3) and 3 no. 23 REACH Regulation.",
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""
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""
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"MaterialDescription": "CE,Ps.species,Lyo.,SQ",
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"Chapters": [
{
"Language": "en",
"Value": "Use Cholesterol Esterase in diagnostic tests for the determination of cholesterol in combination with Cholesterol Oxidase, Catalog Nos. 10 634 522 103, or 11 479 709 103.",
"Country": "XG",
"Code": "Applications",
"Name": "Applications"
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{
"Language": "en",
"Value": "Will be supplied as \"CE, Ps.species, Lyo., SQ\". Unit of measure is \"MU\".",
"Country": "XG",
"Code": "CB - Order Information",
"Name": "CB - Order Information"
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{
"Language": "en",
"Value": "Hydrolase that splits fatty acids from sterols.",
"Country": "XG",
"Code": "Positioning",
"Name": "Positioning"
},
{
"Language": "en",
"Value": "
Appearance: Brownish lyophilizate
Solubility: Clear, brown solution in water (c=50 mg/mL)
pH value (c=50 mg/mL in water): 7.0-8.0
Activity (+25°C, cholesterol oleate): ≥100 U/mg lyophilizate
Specific Activity: ≥100 U/mg protein
Protein (Biuret): No limit
Contaminants (expressed as percentage of Cholesterol Esterase activity):
ATPase: ≤0.005
Catalase: ≤1.00
Glycerokinase: ≤0.001
Glucose oxidase: ≤0.001
Hexokinase: ≤0.005
\"NADH oxidase\": ≤0.001
Uricase: ≤0.005
Stability: At +2 to +8°C within specification range for 12 months. Store dry.",
"Country": "XG",
"Code": "Specification",
"Name": "Specification"
},
{
"Language": "en",
"Value": "
Nomenclature: Sterol-ester acylhydrolase
CAS Number: 9026-00-0
Molecular weight: ~129 kD
Isoelectric point: 4.5
Michaelis constant (Phosphate buffer, pH 7.5):
Cholesterol oleate: 7 x 10
-5 mol/L
Inhibitors: Heavy metals such as Cu
2+, Ag
+, Zn
2+Activators: Detergents
pH optimum: 6.0-8.0; (maximum at pH 7.6) (see figure)
Temperature dependence: Not possible to determine under assay conditions due to turbidity of Thesit at temperatures above +27°C.
pH stability: 6.0-6.5 (see figure)
Thermal stability: Below +20°C (see figure)
Specificity: Cholesterol esterase is an enzyme of lipid metabolism and gives complete cleavage of all serum cholesterol esters.
Remark: This Cholesterol esterase is especially suited for liquid stable applications with extended shelf life requirements.",
"Country": "XG",
"Code": "Properties",
"Name": "Properties"
}
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}
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}