{ "ProductData": { "ID": "3.1.3.2.3.2", "ProductType": "Others", "BrandName": "Carboxypeptidase B, recombinant", "ProductNameAddition": "from rat pancreas, expressed in Pichia pastoris, solution", "RegulatoryDisclaimer1": "For further processing only.", "DisclaimerGroup1": "", "RegulatoryDisclaimer2": null, "DisclaimerGroup2": null, "RegulatoryDisclaimer3": null, "SampleType": [ ], "LicenseDisclaimers": [ ], "RelatedLinks": "", "Clone": "", "ControlTissue": [ "" ], "ISOtypes": "", "Species": [ "" ], "StainLocalization": [ "" ], "ProductNameGlobal": "Carboxypeptidase B recombinant from rat pancreas expressed in Pichia pastoris solution" }, "ProductImageDetails": { "ImagePath": "https://pim-media.roche.com/Images/CB_IMAGE_.png", "ImageType": "Image main" }, "Product2Taxonomy": { "Product2TaxonomyReferences": [ { "StructureSystemIdentifier": "OWP_Product_Types", "StructureSystemName": "Product Types", "NodeID": "70-044-00", "StructureNodeStatus": "valid", "NodeName": "Proteases" }, { "StructureSystemIdentifier": "OWP_Organization", "StructureSystemName": "Organization", "NodeID": "01-01-01-07-00", "StructureNodeStatus": "valid", "NodeName": "CustomBiotech and LifeScience" }, { "StructureSystemIdentifier": "Product_Solutions", "StructureSystemName": "Product Solutions", "NodeID": "520", "StructureNodeStatus": "valid", "NodeName": "CustomBiotech" }, { "StructureSystemIdentifier": "Lab_Type", "StructureSystemName": "Lab Types", "NodeID": "180-00", "StructureNodeStatus": "invalid", "NodeName": "" }, { "StructureSystemIdentifier": "Applications", "StructureSystemName": "Applications", "NodeID": "99-00-00", "StructureNodeStatus": "invalid", "NodeName": "" }, { "StructureSystemIdentifier": "OWP_Techniques", "StructureSystemName": "Techniques", "NodeID": "999-00", "StructureNodeStatus": "invalid", "NodeName": "" }, { "StructureSystemIdentifier": "Disease_Areas", "StructureSystemName": "Disease Areas", "NodeID": "99-00-00", "StructureNodeStatus": "invalid", "NodeName": "" }, { "StructureSystemIdentifier": "Pathogens", "StructureSystemName": "Pathogens", "NodeID": "99-00-00", "StructureNodeStatus": "invalid", "NodeName": "" }, { "StructureSystemIdentifier": "OWP_Family", "StructureSystemName": "Product Families", "NodeID": "999", "StructureNodeStatus": "invalid", "NodeName": "" }, { "StructureSystemIdentifier": "Health_Topics", "StructureSystemName": "Health Topics", "NodeID": "99-00-00", "StructureNodeStatus": "invalid", "NodeName": "" }, { "StructureSystemIdentifier": "Product_Grouping", "StructureSystemName": "Product Grouping", "NodeID": "02-0133", "StructureNodeStatus": "valid", "NodeName": "Cell and Gene Therapy" }, { "StructureSystemIdentifier": "Product_Grouping", "StructureSystemName": "Product Grouping", "NodeID": "02-0112", "StructureNodeStatus": "valid", "NodeName": "Protease Portfolio" }, { "StructureSystemIdentifier": "Product_Grouping", "StructureSystemName": "Product Grouping", "NodeID": "02-0014", "StructureNodeStatus": "valid", "NodeName": "Enzymes" }, { "StructureSystemIdentifier": "Product_Grouping", "StructureSystemName": "Product Grouping", "NodeID": "02-0008", "StructureNodeStatus": "valid", "NodeName": "Biologics" } ] }, "Product2Materials": { "P2MaterialReferences": [ { "MaterialNum": "07042736001", "MaterialDescription": "Carboxypeptidase B rec. 3 x 30 kU", "RegisteredProductName": "Carboxypeptidase B rec.", "GTIN": "", "ProductCategoryText": "Reagents, kits", "OldMaterialNumber": "", "PackSizePIM360": "3 x 30 kU", "PackSizeDescPIM360": "Not Available", "MaterialAnnotation": "", "ReadyForUse": "", "OrderInformation": "Will be supplied as \"CpB rec.\". Unit of measure is \"MU\"." }, { "MaterialNum": "03358682103", "MaterialDescription": "CpB rec.", "RegisteredProductName": "Carboxypeptidase B, recombinant", "GTIN": "07613336131336", "ProductCategoryText": "Reagents, kits", "OldMaterialNumber": "", "PackSizePIM360": "0.03 MU", "PackSizeDescPIM360": "Not Available", "MaterialAnnotation": "CustomBiotech product. Please contact your local representative.", "ReadyForUse": "", "OrderInformation": "Will be supplied as \"CpB rec.\". Unit of measure is \"MU\"." } ] }, "Product2Products": { "Product2ProductReference": [ { "ProductID": "3.1.3.7.21.1", "BrandName": "Trypsin, recombinant", "ProductNameAddition": "Expressed in Pichia pastoris", "ReferenceType": "Reagent", "Classification": [ { "IdentifierofStructureSystem": "OWP_Product_Types", "NameofStructureSystem": "Product Types", "StructureNodeID": "70-044-00", "StructureGroupPath": "Raw Materials->Proteases", "StructureGroupName": "Proteases", "StructureNodeStatus": "valid" }, { "IdentifierofStructureSystem": "Product_Grouping", "NameofStructureSystem": "Product Grouping", "StructureNodeID": "02-0133", "StructureGroupPath": "CustomBiotech->Cell and Gene Therapy", "StructureGroupName": "Cell and Gene Therapy", "StructureNodeStatus": "valid" }, { "IdentifierofStructureSystem": "OWP_Organization", "NameofStructureSystem": "Organization", "StructureNodeID": "01-01-01-07-00", "StructureGroupPath": "Roche Diagnostics Solution (RDS)->Customer Areas->Core lab->CustomBiotech and LifeScience", "StructureGroupName": "CustomBiotech and LifeScience", "StructureNodeStatus": "valid" }, { "IdentifierofStructureSystem": "Product_Solutions", "NameofStructureSystem": "Product Solutions", "StructureNodeID": "520", "StructureGroupPath": "CustomBiotech", "StructureGroupName": "CustomBiotech", "StructureNodeStatus": "valid" }, { "IdentifierofStructureSystem": "Lab_Type", "NameofStructureSystem": "Lab Types", "StructureNodeID": "180-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "invalid" }, { "IdentifierofStructureSystem": "Applications", "NameofStructureSystem": "Applications", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "invalid" }, { "IdentifierofStructureSystem": "OWP_Techniques", "NameofStructureSystem": "Techniques", "StructureNodeID": "999-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "invalid" }, { "IdentifierofStructureSystem": "Disease_Areas", "NameofStructureSystem": "Disease Areas", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "invalid" }, { "IdentifierofStructureSystem": "Pathogens", "NameofStructureSystem": "Pathogens", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "invalid" }, { "IdentifierofStructureSystem": "OWP_Family", "NameofStructureSystem": "Product Families", "StructureNodeID": "999", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "invalid" }, { "IdentifierofStructureSystem": "Health_Topics", "NameofStructureSystem": "Health Topics", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "invalid" }, { "IdentifierofStructureSystem": "Product_Grouping", "NameofStructureSystem": "Product Grouping", "StructureNodeID": "02-0008", "StructureGroupPath": "CustomBiotech->Biologics", "StructureGroupName": "Biologics", "StructureNodeStatus": "valid" }, { "IdentifierofStructureSystem": "Product_Grouping", "NameofStructureSystem": "Product Grouping", "StructureNodeID": "02-0112", "StructureGroupPath": "CustomBiotech->Protease Portfolio", "StructureGroupName": "Protease Portfolio", "StructureNodeStatus": "valid" } ] }, { "ProductID": "3.6.14.8.1.6", "BrandName": "Proteinase K, rec., PCR Grade, sol.", "ProductNameAddition": "from Titrirachium album, expressed in Pichia pastoris, solution", "ReferenceType": "Reagent", "Classification": [ { "IdentifierofStructureSystem": "OWP_Product_Types", "NameofStructureSystem": "Product Types", "StructureNodeID": "70-044-00", "StructureGroupPath": "Raw Materials->Proteases", "StructureGroupName": "Proteases", "StructureNodeStatus": "valid" }, { "IdentifierofStructureSystem": "OWP_Organization", "NameofStructureSystem": "Organization", "StructureNodeID": "01-01-01-07-00", "StructureGroupPath": "Roche Diagnostics Solution (RDS)->Customer Areas->Core lab->CustomBiotech and LifeScience", "StructureGroupName": "CustomBiotech and LifeScience", "StructureNodeStatus": "valid" }, { "IdentifierofStructureSystem": "OWP_Techniques", "NameofStructureSystem": "Techniques", "StructureNodeID": "241-00", "StructureGroupPath": "Nucleic Acid Extraction and Purification", "StructureGroupName": "Nucleic Acid Extraction and Purification", "StructureNodeStatus": "valid" }, { "IdentifierofStructureSystem": "OWP_Techniques", "NameofStructureSystem": "Techniques", "StructureNodeID": "130-00", "StructureGroupPath": "Sample Preparation", "StructureGroupName": "Sample Preparation", "StructureNodeStatus": "valid" }, { "IdentifierofStructureSystem": "Product_Solutions", "NameofStructureSystem": "Product Solutions", "StructureNodeID": "520", "StructureGroupPath": "CustomBiotech", "StructureGroupName": "CustomBiotech", "StructureNodeStatus": "valid" }, { "IdentifierofStructureSystem": "Lab_Type", "NameofStructureSystem": "Lab Types", "StructureNodeID": "180-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "invalid" }, { "IdentifierofStructureSystem": "Applications", "NameofStructureSystem": "Applications", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "invalid" }, { "IdentifierofStructureSystem": "Disease_Areas", "NameofStructureSystem": "Disease Areas", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "invalid" }, { "IdentifierofStructureSystem": "Pathogens", "NameofStructureSystem": "Pathogens", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "invalid" }, { "IdentifierofStructureSystem": "OWP_Family", "NameofStructureSystem": "Product Families", "StructureNodeID": "999", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "invalid" }, { "IdentifierofStructureSystem": "Health_Topics", "NameofStructureSystem": "Health Topics", "StructureNodeID": "99-00-00", "StructureGroupPath": "", "StructureGroupName": "", "StructureNodeStatus": "invalid" }, { "IdentifierofStructureSystem": "Product_Grouping", "NameofStructureSystem": "Product Grouping", "StructureNodeID": "02-0133", "StructureGroupPath": "CustomBiotech->Cell and Gene Therapy", "StructureGroupName": "Cell and Gene Therapy", "StructureNodeStatus": "valid" }, { "IdentifierofStructureSystem": "Product_Grouping", "NameofStructureSystem": "Product Grouping", "StructureNodeID": "02-0112", "StructureGroupPath": "CustomBiotech->Protease Portfolio", "StructureGroupName": "Protease Portfolio", "StructureNodeStatus": "valid" }, { "IdentifierofStructureSystem": "Product_Grouping", "NameofStructureSystem": "Product Grouping", "StructureNodeID": "02-0014", "StructureGroupPath": "CustomBiotech->Enzymes", "StructureGroupName": "Enzymes", "StructureNodeStatus": "valid" } ] } ] }, "ProductSpec": [ { "ProductSpecVariant": { "Chapters": [ { "Name": "Product Description", "Value": "Carboxypeptidase B is a widely used metalloprotease, typically isolated from pancreas of different animals, that specifically releases arginine and lysine from the C-terminus of peptides and proteins. Roche has chemically synthesized a gene encoding for the amino acid sequence of the rat Carboxypeptidase B and has transformed the gene into the expression host Pichia pastoris, which expresses the recombinant Carboxypeptidase B as active protease with identical properties compared to the native Carboxypeptidase B.The production process is validated resulting in a very high lot-to-lot consistency.", "Language": "en", "Country": "XG", "Code": "Product Description" }, { "Name": "Applications", "Value": "Use the animal component-free and DIN EN ISO 13485-manufactured Carboxypeptidase B, recombinant, as critical raw material for the production of active pharmaceutical ingredients (API), i.e., insulin.", "Language": "en", "Country": "XG", "Code": "Applications" }, { "Name": "CB - Order Information", "Value": "Will be supplied as \"CpB rec.\". Unit of measure is \"MU\".

 ", "Language": "en", "Country": "XG", "Code": "CB - Order Information" }, { "Name": "Positioning", "Value": "Carboxypeptidase B, recombinant, is intended to use in highly regulated production processes at pharmaceutical companies.", "Language": "en", "Country": "XG", "Code": "Positioning" }, { "Name": "Benefits", "Value": "
  • Minimize the risk of virus contamination and the risk of animalrelated cross-contamination.
  • Rely on high purity. Minimize the risk of host cell protein contamination in your final product.
  • Increase the safety of your production processes with robust and reproducible performance and high lot-to-lot consistency.
", "Language": "en", "Country": "XG", "Code": "Benefits" }, { "Name": "Quality Control", "Value": "Carboxypeptidase B, recombinant, is produced completely animal component-free and according to DIN EN ISO 13485.", "Language": "en", "Country": "XG", "Code": "Quality Control" }, { "Name": "Background Information", "Value": "For several years Roche has successfully pursued the strategy of replacing animal-derived enzymes, frequently used in pharmaceutical production processes with recombinant, animal component-free enzymes.
Related products are recombinant Trypsin, recombinant Proteinase K, recombinant DNase I and others.", "Language": "en", "Country": "XG", "Code": "Background Information" }, { "Name": "Properties", "Value": "CAS Number: 9025-24-5
Molecular weight: 34.6 kD
The product is manufactured according to DIN EN ISO 13485 .
No animal-derived products are used in the fermentation, purification and final formulation.", "Language": "en", "Country": "XG", "Code": "Properties" }, { "Name": "Specification", "Value": "Appearance: Clear, colorless to slightly yellowish solution
Storage buffer: Tris/HCl, 33 mmol/L; ZnCl2, 0.1 mmol/L
pH (at +25°C): 7.5-8.5
Activity (with hippurylarginine): ≥400 U/mL
Total activity: 30 kU ±15%
Specific activity: ≥210 U/mg
Protein: 2.8±0.5 mg/mL
Purity (RP-HPLC): ≥85% according to master lot
Bioburden: ≤50 CFU/mL
Trypsin (with chromozym): ≤0.005%
Shipping conditions: Dry ice
Stability: At -15 to -25°C within specification range for 12 months.", "Language": "en", "Country": "XG", "Code": "Specification" } ] } } ] }

Carboxypeptidase B, recombinant

from rat pancreas, expressed in Pichia pastoris, solution

logo

Ordering Information

Technical documents

for certificates, method sheets (instructions for use), safety data sheets and software downloads
error errorMessage
Sorry, we couldn't find the content you are looking for
Please try again later