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"α-2,6-Sialyltansferase, rec. EQ is a highly active recombinant human glycosyltransferase, expressed in CHO cells.

To use in vitro glycoengineering in drug development and manufacturing processes, enzymes should be of enhanced quality (EQ), compared to enzymes used in early R&D or analytical applications: Enzymes should be tested for host-cell impurities and relevant metal impurities and be available at least in gram amounts .
α-2,6-Sialyltansferase, rec. EQ fulfills those criteria and can also be provided in GMP Grade upon request.", "Name": "Product Description" }, { "Language": "en", "Value": "Incubation of α-2,6-Sialyltansferase and CMP-NANA with a glycoprotein leads to increased sialylation of the glycoprotein.

As α-2,6-Sialyltansferase rec. EQ adds sialic acid only to galactosylated glycostructures, a galactosylation of the glycoprotein in a previous step helps to achieve higher sialylation levels. Galactosylation can be achieved by incubation of the target protein with ß-1,4-Galactosyltransferase and UDP-Galactose.", "Name": "Applications" }, { "Language": "en", "Value": "α-2,6-Sialyltransferase, rec. EQ can be used for in vitro glycoengineering of glycoproteins, e.g. therapeutic proteins, in drug development and manufacturing.", "Name": "Positioning" }, { "Language": "en", "Value": "Benefits of using in vitro glycoengineering to modify glycosylation of therapeutic proteins:
  • Time- and cost-saving generation of glycan variants to facilitate drug development.
  • Optimized glycosylation without compromising other CQAs or product yield.
  • Improved lot-to-lot consistency to reduce risk of product quality variation and resulting delays.
  • Generation of glycoprofiles which may not otherwise be generated.
  • Streamlined analytics in comparability studies.
", "Name": "Benefits" }, { "Language": "en", "Value": "No animal-derived material is added in fermentation, purification, and final formulation of this enzyme.", "Name": "Quality Control" }, { "Language": "en", "Value": "Appearance: Clear and colorless to slightly yellowish solution
Specific activity: ≥400 U/μg
Protein (OD 280 nm) A280 = 1.931: 15 ± 1.5 mg/mL
Purity (HPLC): >90%
Bioburden: ≤100 CFU/mL
Endotoxin: ≤10 EU/mg
Host cell protein: ≤ 4000 ppm
Host cell DNA: ≤ 100 pg/mg
Heavy metal (Cd, Co, V, Ni, Ag, Se): ≤ 10 ppm
Stability: At –15 to –25°C within specification range for 18 months (08 098 174 103) and 12 months (08 098 174 101).", "Name": "Specification" } ] } } ] }

α-2,6-Sialyltransferase, rec. EQ

human, expressed in CHO-K1 cells

α-2,3-Sialyltransferase

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