Evaluating mRNA capping systems
Evaluating mRNA capping systems: experimental strategies for mRNA manufacturing
Tuesday, September 30, 2025
08:00 PDT / 11:00 EDT / 16:00 BST / 17:00 CEST
As mRNA-based therapeutics continue to evolve, the need for robust, scalable, and high-yield manufacturing processes has never been greater. Robust and cost-effective mRNA capping is critical to ensuring high-quality, stable, and efficient RNA products, while making new vaccines and therapeutics more accessible to the broader market.
In this webinar, comparative performance data and practical insights will be shared to help you evaluate and optimize your capping processes. We will also explore characterization techniques, including cell-based potency assays and how mass spectrometry can be used to assess capping efficiency and inform process design for improved mRNA stability and translation.
Attend this webinar to:
- Learn methodologies for optimizing the IVT and capping procedures to fit your target product, including methods of streamlining the capping reaction suitable to the type of molecule
- See comparative performance data of various capping solutions, including a novel capping system, highlighting how these impact critical quality attributes, such as capping efficiency, mRNA yield and potency, both for non-self-amplifying and self-amplifying RNA
- Understand available key technologies and learn strategies to thoroughly assess and characterize raw materials for mRNA manufacturing
- Gain practical tips on optimizing an efficient mRNA capping reaction and determine the optimal ratio of capping enzymes to mRNA