Proteases for protein cleavage and protein processing

Proteases portfolio illustration

High-quality proteases like Trypsin and Carboxypeptidase, rec., GMP Grade for biopharmaceutical manufacturing

Streamline your production with our extensive portfolio of proteolytic enzymes. From highly specific cleavage for Active Pharmaceutical Ingredients (API) to general protein degradation, we provide the precision and reliability required for critical raw materials.

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Tailored enzymatic solutions

Select the ideal protease engineered for your specific process requirements:

Selective cleavage

High-purity proteases designed for the processing of critical therapeutic agents, such as insulin and vaccine production.

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Tissue dissociation

Specialized enzymes engineered for efficient and gentle cell isolation workflows.
 

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Total protein degradation

Potent proteases for complete hydrolysis and protein removal applications.

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Quality and compliance

Ensure the safety and reproducibility of your downstream processes. All our enzymes are manufactured to adhere to rigorous industry standards:

Certified quality management system

CustomBiotech has a QMS that is certified according to ISO 13485:2016

 

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Process stability 

High lot-to-lot consistency ensures reproducible results, minimizing validation efforts and process variability.

 

Endoproteases

 

Trypsin, rec., GMP Grade is expressed in the yeast Pichia pastoris. This procedure in fermentation and enzyme processing eliminates the risk of endotoxins and animal-derived material. No other proteases are used for downstream processing, making this product highly pure, extremely active, and free of any animal-derived material. This makes Trypsin, rec., GMP Grade suited for regulated production environments.

Collagenases

 

Collagenase I and II are ultrapure, mammalian- and avian-free enzymes dedicated for tissue dissociation. Mild and consistent conditions are essential for high viability and yield of isolated cells. To achieve this, Roche has developed exclusive combinations of our collagenases and neutral proteases offered as Liberase enzyme blends. Customized enzyme combinations are offered on request completing our offering.

Exoproteases

 

Carboxypeptidase B, rec., GMP Grade expressed in Pichia pastoris is optimal for sensitive manufacturing workflows in biopharma applications, such as active insulin production and post-translational modification of antibodies. Our CpB is animal-component-free and of high performance. Each lot meets narrow quality and activity specifications saving time and money.

Protease inhibitors

 

Preventing or interrupting protein degradation complements the Roche CustomBiotech protease portfolio in a useful manner. Choose from a variety of different protease inhibitors depending on the protease you need to block.

Regulatory disclaimers are listed on the respective product page.

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