Protease portfolio

Achieve reproducible performance and high yields without risk of viral and microbial contamination in your final product. Our highly pure proteases are specifically designed for use as critical raw materials in the production of Active Pharmaceutical Ingredients (API), such as in insulin or vaccine production.



Visit selection guide
to navigate through our protease portfolio




CustomBiotech has cloned trypsin into the yeast Pichia pastoris for recombinant gene expression and produced according to DIN EN ISO 13485. This procedure in fermentation and enzyme processing eliminates the risk of animal-derived material. No other proteases are used for downstream processing, making this product highly pure, extremely active, and free of any animal-derived material. Recombinant Trypsin is therefore ideal, even in regulated production environments.

Additional to the recombinant Trypsin Roche offers a wide selection of endoproteases that cleave peptides and proteins at the C- or N-terminal site of specific single amino acids. These proteases provide high lot-to-lot consistency and reproducibility, and are produced without animal components and according to DIN EN ISO 13485. Some of the endoproteinases are available as enzymes purified according to standard purification protocols or specifically designed purification protocols, making these enzymes particularly suitable for custom peptide mapping or proteomics applications.

Serine proteases

Flyer:                       Rec. Trypsin, GMP Grade 
Flyer:                       Residual Protein Trypsin Kit
Application note:     Rec.Trypsin in cell culture applications                         


Cysteine proteases

Product details for:

Papain, suspension




Product details for:

Carboxypeptidase B, rec.


Carboxypeptidase B, rec.


Mix of nonspecific endo- and exoproteases

Product details: Pronase


Protease inhibitors