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Pepstatin

from Streptomyces species, lyophilizate

For further processing only.

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Order information
Pepstatin material number and pack size:
Material Number Pack Size
10253294103 custom fill
Will be supplied as "Pepstatin from Sreptomyces species". Unit of measure is "g".
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Overview
Pepstatin is a protease inhibitor.
Pepstatin is a highly efficient inhibitor for many aspartic and acid proteases. It is a hexa-peptide containing the unusual amino acid statine (Sta, (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid), having the sequence Iva-Val-Val-Sta-Ala-Sta. Pepstatin is known for its ability to inhibit pepsin in a picomolar concentration. The product is soluble in methanol and ethanol, but insoluble in water.
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Application
Use Pepstatin to inhibit potently the HIV protease and other aspartic proteases such as pepsin, renin, cathepsin D, chymosin, and many microbial acid proteases.
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Specification
Formula: C34H63N5O9
Molecular weight: 685.9 D
Pepstatin is soluble in methanol (1 mg/mL and 20 mg/mL as well) and ethanol (1 mg/ml) if you allowed to sit overnight, and to 300 μg/ml in 6 N acetic acid. Stable at least 1 week at +2 to +8°C or 1 month if stored in aliquots at -15 to -25°C.
Appearance: White powder
Solubility:
Clear to slightly opalescent, colorless solution in methanol (c=1 mg/mL)
Clear, colorless solution in methanol (c=20 mg/mL)
Clear to slightly opalescent, colorless solution in ethanol (overnight)
Performance of inhibition of pepsin:
With 0.01 mL sample: ≥85%
With 0.1 mL sample: ≥100%
Values are taken from supplier certificate:
Melting range: +232 to +237°C
Purity (HPLC): ≥98 area%
Stability: At +2 to +8°C within specification range for 24 months.